Mitoxantrone

SKU
M-2381
  • CAS:65271-80-9
  • Formula:C22H28N4O6
  • MW:444.48 Da
  • Appearance:Dark blue soild
  • Purity:≥98%

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Product Name Qty
Mitoxantrone
50 mg
$74.04
Mitoxantrone
250 mg
$296.16

An anti-tumor antibiotic and type II topoisomerase inhibitor. It disrupts DNA synthesis and DNA repair in both healthy and cancer cells. Mitoxantrone also displays broad immunosuppressive activity inhibiting proliferation of all classes of lymphocytes and inducing apoptosis of antigen-presenting T cells.

More Information
Alternate Name/Synonyms
Mitozantrone; DHAQ; Novantrone; Dihydroxyanthraquinone
SKU
M-2381
CAS #
65271-80-9
Chemical Name
1,4-dihydroxy-5,8-bis[2-(2-hydroxyethylamino)ethylamino]anthracene-9,10-dione
Chemical Formula
C22H28N4O6
Molecular Weight
444.48 Da
Appearance
Dark blue soild
Purity
≥98%
Solubility
Soluble in DMSO.
Melting Point
170-174 °C
Storage Temp
-20°C, desiccated
THERAPEUTIC AREA
Oncological Disorders
USE
Mitoxantrone is a DNA intercalating drug that inhibits DNA synthesis and is used as an anti-cancer agent. Mitoxantrone is an inhibitor of Topoisomerase II.
MDL NUMBER
MFCD00242942
CHEMACX
X1012957-6
INCHI
InChI=1S/C22H28N4O6/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32/h1-4,23-30H,5-12H2
SMILES
c1cc(c2c(c1NCCNCCO)C(=O)c3c(ccc(c3C2=O)O)O)NCCNCCO
Peptide sequence
Not Applicable
RTECS
CB5748500
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation.
Certificate of Analysis 1
GHS PICTOGRAMS
Handling Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation.
UN #'S Not Applicable
Packing Group Not Applicable
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