MK-2206

SKU
M-2382
  • CAS:1032350-13-2
  • Formula:C25H21N5O .2HCl
  • MW:480.39
  • Appearance:Crystalline solid
  • Purity:≥98% by HPLC
Product Name Qty
MK-2206
500 ug
$96.82
MK-2206
1 mg
$176.55

A highly selective non-ATP competitive allosteric Akt inhibitor with IC50’s of 8 nM, 2 nM and 65 nM for Akt1, Akt2 and Akt3, respectively. MK-2206 potently inhibits phosphorylation of Thr³⁰⁸ and Ser⁴⁷³ in 3T3-L1 adipocytes with IC50 values of 0.11 and 0.18 µM, respectively as well as downstream effects of insulin on GLUT4 translocation (IC50 = 0.47 µM) and glucose transport (IC50 = 0.14 µM). In addition, treatment with MK-2206 causes a robust, concentration-dependent activation of autophagy in human glioma cell lines LN229 and T98G.

More Information
SKU
M-2382
CAS #
1032350-13-2
Chemical Name
8-(4-(1-Aminocyclobutyl)phenyl-9-phenyl[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one dihydrochloride
Chemical Formula
C25H21N5O .2HCl
Molecular Weight
480.39
Appearance
Crystalline solid
Purity
≥98% by HPLC
Solubility
DMSO
Storage Temp
-20°C
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