The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in apoptosis and hence cancer (e.g.breast cancer and glioblastoma)The phosphatidylinositol 3-kinases (PI3Ks) are a family of lipid kinases whose primary biochemical function is to phosphorylate the 3-hydroxyl group of phosphoinositides PI3K activation activates AKT. AMP-activated protein kinase (AMPK) was initially identified as a serine/threonine kinase that negatively regulates several key enzymes of the lipid anabolism. AMPK is regarded as the major energy-sensing kinase that activates a whole variety of catabolic processes in multicellular organisms such as glucose uptake and metabolism, while simultaneously inhibiting several anabolic pathways, such as lipid, protein, carbohydrate biosynthesis and mTOR.

The proline-rich Akt substrate of 40 kDa (PRAS40) acts at the intersection of the Akt- and mammalian target of rapamycin (mTOR)-mediated signaling pathways. The protein kinase mTOR is the catalytic subunit of two distinct signaling complexes, mTOR complex 1 (mTORC1) and mTORC2, that link energy and nutrients to the regulation of cellular growth and energy metabolism. Alterations in Akt and mTOR activity have been linked to the progression of multiple diseases such as cancer and type 2 diabetes.

 

 Click Here to View the mTOR Signaling Pathway

Desc

17 Items

per page
  1. Anisomycin | CAS 22862-76-6 | Anti-fungal antibiotic | AG Scientific
    Anisomycin (Flagecidin)
    A-1049

    Starting at $40.79

  2. BEZ235
    BEZ235
    B-2199

    Starting at $142.38

  3. DiscoveryPak PI 3-Kinase Inhibitor Set
    DiscoveryPak PI 3-Kinase Inhibitor Set
    D-2292

    Starting at $495.50

  4. GDC-0941
    GDC-0941
    G-2335

    Starting at $182.11

  5. IC87114
    IC87114
    I-2356

    Starting at $222.12

  6. KU-55933
    KU-55933
    A-2189

    Starting at $187.95

  7. LY294002 EZSolution™
    LY294002 EZSolution™
    E-2312

    Starting at $91.13

  8. Neomycin Sulfate chemical structure | CAS 1405-10-3 | AG Scientific,  Inc.
    Neomycin Sulfate, USP
    N-1053

    Starting at $49.00

  9. PathwayReady PI3-K/Akt/mTOR Signaling Inhibitor Panel
    PathwayReady PI3-K/Akt/mTOR Signaling Inhibitor Panel
    P-2384

    Starting at $1,065.03

  10. Phosphatidylinositol 3-Kinase SH3 Domain Binding Peptide
    Phosphatidylinositol 3-Kinase SH3 Domain Binding Peptide
    P-1143

    Starting at $100.25

  11. PI diC8
    PI diC8
    P-1555

    Starting at $244.90

  12. PI(3)diC16
    PI(3)diC16
    P-1557

    Starting at $244.90

  13. PI-103
    PI-103
    P-2394

    Starting at $102.52

  14. PI3-K gamma Inhibitor, AS-605240
    PI3-K gamma Inhibitor, AS-605240
    P-2395

    Starting at $74.04

  15. TGX-221
    TGX-221
    T-2460

    Starting at $96.82

  16. Umirolimus
    Umirolimus
    U-2581

    Starting at $117.33

  17. Wortmannin
    Wortmannin
    W-1022

    Starting at $53.04

Desc

17 Items

per page
To Top