MS-275, HDAC inhibitor

SKU
M-3331
  • CAS:209783-80-2
  • Formula:C21H20N4O3
  • MW:376.42
  • Appearance:Pale yellow solid
  • Purity:98% by TLC NMR (Conforms)
Product Name Qty
MS-275, HDAC inhibitor
25 mg
$170.79

MS-275 (209783-80-2) is a potent HDAC inhibitor. Selective for HDAC1 (IC50 = 300 nM) over HDAC3 (IC50 = 8 μM) and HDAC8 (IC50 100 μM). In vivo, MS-275, has been shown to inhibit tumor growth via induction of the tumor supressors p21WAF1/CIP1 and gelsolin and to block cell proliferation in a variety of cancer cell lines. MS-275 has also shown significant anti-rheumatic activity in rat and mouse arthritis models.

More Information
Alternate Name/Synonyms
Entinostat
SKU
M-3331
CAS #
209783-80-2
Chemical Formula
C21H20N4O3
Molecular Weight
376.42
Appearance
Pale yellow solid
Purity
98% by TLC NMR (Conforms)
Solubility
Soluble in DMSO (up to 25 mg/ml).
Stability
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
Storage Temp
-20°
Hazard Image
Yes
Promo text for AGS discount
N/A
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