Mycalolide B

SKU
M-1171
  • CAS:122752-21-0
  • Formula:C52H74N4O17
  • MW:1027.2 Da
  • Appearance:Colorless lyophilized wax
  • Purity:≥98%

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Product Name Qty
Mycalolide B
100 ug
$638.44
Mycalolide B
20 ug
$319.23

Isolated from the marine sponge Mycale sp. Inhibits actin polymerization. Depolymerizes F-actin by nibbling and forms a 1:1 complex with G-actin

Custom synthesized to order lead time: 4-7 days

More Information
Alternate Name/Synonyms
4-O-Acetyl-21-O-de(aminocarbonyl)-23,24-didehydro-39,46-dinor-6-deoxo-25-deoxy-6-(2,3-dimethoxy-1-oxopropoxy)-25-oxokabiramide C
SKU
M-1171
CAS #
122752-21-0
Chemical Name
[(E,3R,4R,5S,6R,9S,10S)-4-acetyloxy-1-[formyl(methyl)amino]-11-[(10S,11R,13E,16S,20S,21R,22S,24E)-16-hydroxy-10,22-dimethoxy-11,21-dimethyl-12,18-dioxo-3,7,19,27-tetraoxa-29,30,31-triazatetracyclo[24.2.1.12,5.16,9]hentriaconta-1(28),2(31),4,6(30),8,13,24,
Chemical Formula
C52H74N4O17
Molecular Weight
1027.2 Da
Appearance
Colorless lyophilized wax
Purity
≥98%
Solubility
DMSO (20 mg/mL) or water (2 mg/mL)
Melting Point
N/A
Preparation
N/A
Storage Temp
-20°C, desiccated
THERAPEUTIC AREA
Not Available
USE
Mycalolide B has been shown to inhibit actin polymerization (IC50=10-50 nM) with a different mechanism of action from cytochalasin D. It suppresses actin-activated myosin Mg2+-ATPase activity without changing myosin light chain phosphorylation resulting in inhibition of smooth muscle contractions. Mycalolide B depolymerizes F-actin at differing concentrations by nibbling and forms a 1:1 complex with G-actin. Mycalolide B, at a concentration of 3 μM, abolished both ADP (10 μM)- and collagen (3 μg/ml)-induced platelet aggregation in vitro.
Merck Index
N/A
RTECS
N/A
Handling
Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Corrosive hazard. Wear protective gloves/clothing and eye/face protection.
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
GHS PICTOGRAMS
Handling Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Corrosive hazard. Wear protective gloves/clothing and eye/face protection.
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