N-Acetyl-S-(N′-phenylhexylthiocarbamoyl)-L-cysteine

SKU
N-2761
  • Formula:C18H26N2O3S2
  • MW:382.54
  • Appearance:White to off white powder
  • Purity:≥98%
Product Name Qty
N-Acetyl-S-(N′-phenylhexylthiocarbamoyl)-L-ctsteine
10 mg
$159.77
N-Acetyl-S-(N′-phenylhexylthiocarbamoyl)-L-ctsteine
25 mg
$347.41
N-Acetyl-S-(N′-phenylhexylthiocarbamoyl)-L-ctsteine
100 mg
$1,089.57

N-Acetyl-S-(N’-phenylhexylthiocarbamoyl)-L-cysteine (PHITC) is a cysteine conjugate of N-acetyl-phenylhexylisothiocyanate. Isothiocyanates are typically found in plants of the Brassicaceae family, including broccoli, cabbage, and radish. Isothiocyanates are best known for their antioxidative, anticancer chemotherapeutic, chemopreventive, anti-angiogenic, and antibiotic properties. In vitro, PHITC increases caspase 3 activity and cleavage of poly(ADP)-ribose polymerase (PARP), inducing caspase-mediated apoptosis in cellular models. This compound decreases oxidation of carcinogen NNK and increases activity of NADPH:quinone oxidoreductase and glutathione-S-transferase in vitro and in vivo. PHITC inhibits histone deacetylase (HDAC) activity, IL-6 receptor production, and VEGF expression; it also induces mitochondrial membrane depolarization and apoptosis in myeloma cells. In leukemia cells, PHITC inhibits expression of cyclin and increases expression of CDK inhibitors, inducing apoptosis and inhibiting growth of xenografts of these cells in animals.

More Information
Alternate Name/Synonyms
Acetyl phenylhexylisothiocyanate -L-cysteine
SKU
N-2761
Chemical Formula
C18H26N2O3S2
Molecular Weight
382.54
Appearance
White to off white powder
Purity
≥98%
Storage Temp
-20°C
Hazard Image
Yes
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