N4-Hydroxycytidine (NHC)

SKU
N-3400
  • CAS:3258-02-4
  • Formula:C9H13N3O6
  • MW:259.2 Da
  • Appearance:White powder
  • Purity:>98% by HPLC
Product Name Qty
N4-Hydroxycytidine (NHC)
5 mg
$84.00
N4-Hydroxycytidine (NHC)
25 mg
$315.00

Description

N4-Hydroxycytidine was originally identified as a mutagen effecting AT to GC base-pair transitions1 . It has also been found to have antiviral properties against a broad range of viruses including hepatitis C2, norovirus3 , Ebola virus4 , influenza and respiratory syncytial viruses5 and coronaviruses6 . Active molecule in the antiviral pro-drug clinical candidate EIDD-28017.

Antiviral drug effective against coronavirus.

 

References

N4-hydroxycytidine: A mutagen specific for at to GC transitions
Synergistic In Vitro Interactions between Alpha Interferon and Ribavirin against Bovine Viral Diarrhea Virus and Yellow Fever Virus as Surrogate Models of Hepatitis C Virus Replication
Antiviral activity of nucleoside analogues against norovirus
Identification of a New Ribonucleoside Inhibitor of Ebola Virus Replication
Orally Efficacious Broad-Spectrum Ribonucleoside Analog Inhibitor of Influenza and Respiratory Syncytial Viruses
Inhibition of Human Coronavirus NL63 Infection at Early Stages of the Replication Cycle
• Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin2-one; Beta-D-N4-hydroxycytidine; NHC; Uridine, 4-oxime
SKU
N-3400
CAS #
3258-02-4
Chemical Name
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin-2-one
Chemical Formula
C9H13N3O6
Molecular Weight
259.2 Da
Appearance
White powder
Purity
>98% by HPLC
Solubility
May be dissolved in DMSO (25 mg/mL); or water (15 mg/mL, warm)
Storage Temp
Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 3 months.
THERAPEUTIC AREA
Infectious diseases
USE
Antiviral
Handling
Avoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.
Handling Avoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.
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