Nalidixic Acid Sodium Salt

SKU
N-2653
  • CAS:3374-05-8
  • Formula:C12H11N2NaO3
  • MW:254.22 Da
  • Appearance:White to off-white crystalline powder
  • Purity:≥ 97 %
Product Name Qty
Nalidixic Acid Sodium Salt
25 g
$204.60
Nalidixic Acid Sodium Salt
5 g
$63.43
Nalidixic Acid Sodium Salt
100 g
$731.45

Description

Nalidixic Acid Sodium is the first quinolone-based antibacterial, inhibiting bacterial DNA polymerase and avian myeloblastoma virus reverse transcriptase. It inhibits nucleic acid and protein synthesis in Saccharomyces cerevisiae by suppressing essential bacterial enzymes such as topoisomerases IV and DNA gyrase. It has been reported that, in some specific gram-negative bacteria, Nalidixic Acid shows dose-response patterns of a bactericidal.

In addition, it is used for the treatment of urinary tract infections and is used to study anticancer activity.

 

Applications

• Antibacterial agent

• Used in antitumor studies

 

References

• “A Critical Evaluation of Nalidixic Acid in Urinary-Tract Infections”

• “DNA and protein binding, double-strand DNA cleavage and cytotoxicity of mixed ligand copper(II) complexes of the antibacterial drug nalidixic acid”

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
Baktogram; Nalidixic acid sodium; Sodium nalidixate; Chemiurin; Dixilina
SKU
N-2653
CAS #
3374-05-8
Chemical Name
sodium;1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylate
Chemical Formula
C12H11N2NaO3
Molecular Weight
254.22 Da
Appearance
White to off-white crystalline powder
Purity
≥ 97 %
Solubility
Soluble in water.
Storage Temp
Room temperature
THERAPEUTIC AREA
Antimicrobial
USE
Nalidixic acid sodium salt is an inhibitor of bacterial DNA polymerase (DNA gyrase) and avian myeloblastoma virus reverse transcriptase. It inhibits nucleic acid and protein synthesis in Saccharomyces cerevisiae.
PubChecm ID
3864541
INCHI
ROKRAUFZFDQWLE-UHFFFAOYSA-M
SMILES
CCN1C=C(C(=O)C2=C1N=C(C=C2)C)C(=O)[O-].[Na+]
Handling
Use only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
GHS PICTOGRAMS
HandlingUse only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.
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