Naphthomycin B is an 29-membered naphthalenic ansamacrolactam antibiotic with antimicrobial and antineoplastic activities.

This product is isolated from Streptomyces sp. Gö 40/14.

Ansamycin antibiotics including rifamycin, naphthomycin, ansatrienin(mycotrienin) are structurally related, containing a macrocycle of polyketide origin with an amide linkage to either a naphthalenic or benzenic aromatic moiety. 

Product References

• Isolation and structural elucidation of naphthomycins B and C, Walter Keller-Schierlein, et al, The Journal of Antibiotics, Vol. 36 (1983)

• Cloning and functional analysis fo the naphthomycin biosynthetic gene cluster in Streptomyces sp., Yingying Wu, et al, Mol. BioSyst, 7, 2459-2469 (2011)

• Biosynthesis of ansatrienin(mycotrienin) and naphthomycin, Shuo Chen, et al, European Journal of Biochemistry, vol. 261:98-107 (1999)