SDS
CofA
Description
Cell permeable necrosis inhibitor with antioxidant activity. It localizes mostly in mitochondra. Selectively blocks oxidative stress-induced necrotic cell death. (0.1M Necrosis inhibitor 2 prevented 50% cell death in H9C2 cells exposed to 400M t-BuOOH for 2 hours LDH assay used). Does not protect against staurosporine or etoposide induced apoptosis. Protects cells against cold shock, hypoxia and oxidative stressin vitro.
Applications
In vitro Cell-based assays: Cold Stress, Hypoxia, Oxidative Stress
In vivo Necrosis Animal Models for Liver disease: DILI (Acetaminophen, CCL4), CCL4 induced Liver Fibrosis/Cirrhosis
Ischemia Reperfusion Injury: Stroke, Myocardial Infarction, Acute Pancreatitis Acute Tubular Necrosis
Cell Media: Cell Therapy, CHO Growth
| Handling | Protect from light and moisture. Dissolve in DMSO to 20-50 mM stock solution and dilute further in cell culture media. Treat cells with 30M TO 0.1M final concentration. |
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