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Necrosis Inhibitor-2

SKU
N-1221
  • Formula:C25H32N4O4S2
  • MW:516.67 Da
  • Appearance:Off-white solid
  • Purity:≥95% by HPLC

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Starting at $117.33

Product Name Qty
Necrosis Inhibitor-2
1 mg
$117.33
Necrosis Inhibitor-2
5 mg
$351.97
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Description

Cell permeable necrosis inhibitor with antioxidant activity. It localizes mostly in mitochondra. Selectively blocks oxidative stress-induced necrotic cell death. (0.1M Necrosis inhibitor 2 prevented 50% cell death in H9C2 cells exposed to 400M t-BuOOH for 2 hours LDH assay used). Does not protect against staurosporine or etoposide induced apoptosis. Protects cells against cold shock, hypoxia and oxidative stressin vitro.

Applications

In vitro Cell-based assays: Cold Stress, Hypoxia, Oxidative Stress

In vivo Necrosis Animal Models for Liver disease: DILI (Acetaminophen, CCL4), CCL4 induced Liver Fibrosis/Cirrhosis

Ischemia Reperfusion Injury: Stroke, Myocardial Infarction, Acute Pancreatitis Acute Tubular Necrosis

Cell Media: Cell Therapy, CHO Growth

More Information
Alternate Name/Synonyms
Necrox-2
SKU
N-1221
Chemical Name
[5-(1,1-Dioxo-thiomorpholin-4-ylmethyl)-2-phenyl-1H-indol-7-yl]-(1-methanesulfonyl-piperidin-4-yl)-amine
Chemical Formula
C25H32N4O4S2
Molecular Weight
516.67 Da
Appearance
Off-white solid
Purity
≥95% by HPLC
Solubility
Soluble in DMSO (>10 mg/mL)
Storage Temp
-20°C
THERAPEUTIC AREA
Cardiological Disorders
USE
Use in stroke, myocardial infarction
Handling
Protect from light and moisture. Dissolve in DMSO to 20-50 mM stock solution and dilute further in cell culture media. Treat cells with 30M TO 0.1M final concentration.
Certificate of Analysis 1
N-1221, J1096.pdf
Handling Protect from light and moisture. Dissolve in DMSO to 20-50 mM stock solution and dilute further in cell culture media. Treat cells with 30M TO 0.1M final concentration.
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