Necrosis Inhibitor-2

SKU

N-1221

Formula:C₂₅H₃₂N₄O₄S₂
MW:516.67 Da
Appearance:Off-white solid
Purity:≥95% by HPLC

SDS

CofA

Product Name	Qty
Necrosis Inhibitor-2 1 mg $117.33
Necrosis Inhibitor-2 5 mg $351.97

Details

Description

Cell permeable necrosis inhibitor with antioxidant activity. It localizes mostly in mitochondra. Selectively blocks oxidative stress-induced necrotic cell death. (0.1M Necrosis inhibitor 2 prevented 50% cell death in H9C2 cells exposed to 400M t-BuOOH for 2 hours LDH assay used). Does not protect against staurosporine or etoposide induced apoptosis. Protects cells against cold shock, hypoxia and oxidative stressin vitro.

Applications

In vitro Cell-based assays: Cold Stress, Hypoxia, Oxidative Stress

In vivo Necrosis Animal Models for Liver disease: DILI (Acetaminophen, CCL4), CCL4 induced Liver Fibrosis/Cirrhosis

Ischemia Reperfusion Injury: Stroke, Myocardial Infarction, Acute Pancreatitis Acute Tubular Necrosis

Cell Media: Cell Therapy, CHO Growth

Specifications

More Information

Alternate Name/Synonyms

Necrox-2

SKU

N-1221

CAS #

N/A

Chemical Name

[5-(1,1-Dioxo-thiomorpholin-4-ylmethyl)-2-phenyl-1H-indol-7-yl]-(1-methanesulfonyl-piperidin-4-yl)-amine

Chemical Formula

C₂₅H₃₂N₄O₄S₂

Molecular Weight

516.67 Da

Appearance

Off-white solid

Purity

≥95% by HPLC

Solubility

Soluble in DMSO (>10 mg/mL)

Melting Point

N/A

Preparation

N/A

Storage Temp

-20°C

THERAPEUTIC AREA

Cardiological Disorders

USE

Use in stroke, myocardial infarction

Merck Index

N/A

MDL NUMBER

N/A

CHEMACX

N/A

INCHI

N/A

SMILES

N/A

Peptide sequence

N/A

RTECS

N/A

UN #'S

N/A

PACKING GROUP

N/A

HAZARD CLASS

N/A

Handling

Protect from light and moisture. Dissolve in DMSO to 20-50 mM stock solution and dilute further in cell culture media. Treat cells with 30M TO 0.1M final concentration.

Certificate of Analysis 1

N-1221, J1096.pdf

Reviews

Safety

Handling	Protect from light and moisture. Dissolve in DMSO to 20-50 mM stock solution and dilute further in cell culture media. Treat cells with 30M TO 0.1M final concentration.

Citations