Necrosis Inhibitor-5

SKU
N-1223
  • CAS:1383718-29-3
  • Formula:C25H31N3O3S2 • 2CH4O3S
  • MW:645.83 Da
  • Appearance:Light-pink solid
  • Purity:≥95% (HPLC)

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Product Name Qty
Necrosis Inhibitor-5
1 mg
$153.00
Necrosis Inhibitor-5
5 mg
$351.90

Description

Also known as NecroX-5, this cell permeable necrosis inhibitor has antioxidant activity and localizes mostly in mitochondria. Necrosis Inhibitor-5 selectively blocks oxidative stress-induced necrotic death (0.1M Necrosis Inhibitor 5, prevented 50% cell death in H9C2 cells exposed to 400M t-BuOOH for 2 hours LDH assay used). Does not protect against staurosporine or Etoposide-induced apoptosis. 

Applications

Protects cells against cold shock, hypoxia and oxidative stress in vitro, as well as CCL4- induced acute liver and chronic liver fibrosis in rodent models.

 

More Information
Alternate Name/Synonyms
NecroX-5; Necrox-5 (methanesulfonate)
SKU
N-1223
CAS #
1383718-29-3
Chemical Name
5-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]-N-(oxan-4-ylmethyl)-2-phenyl-1H-indol-7-amine;methanesulfonic acid
Chemical Formula
C25H31N3O3S2 • 2CH4O3S
Molecular Weight
645.83 Da
Appearance
Light-pink solid
Purity
≥95% (HPLC)
Solubility
Soluble in DMSO (10 mg/mL) or distilled water (10 mg/mL)
Storage Temp
-20°C
USE
Necrosis Inhibitor-5 selectively blocks oxidative stress-induced necrotic cell death. It does not protect against staurosporine or etoposide-induced apoptosis. It protects cells against cold shock, hypoxia and oxidative stress in vitro, as well as CCl4 -induced acute liver injury and chronic liver fibrosis in rodent models.
Handling
Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Certificate of Analysis 1
Certificate of Analysis 2
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
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