Necrosis Inhibitor-5

SKU
N-1223
  • CAS:1383718-29-3
  • Formula:C25H31N3O3S2 • 2CH4O3S
  • MW:645.83 Da
  • Appearance:Light-pink solid
  • Purity:≥95% (HPLC)

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Product Name Qty
Necrosis Inhibitor-5
1 mg
$150.00
Necrosis Inhibitor-5
5 mg
$345.00

Description

Also known as NecroX-5, this cell permeable necrosis inhibitor has antioxidant activity and localizes mostly in mitochondria. Necrosis Inhibitor-5 selectively blocks oxidative stress-induced necrotic death (0.1M Necrosis Inhibitor 5, prevented 50% cell death in H9C2 cells exposed to 400M t-BuOOH for 2 hours LDH assay used). Does not protect against staurosporine or Etoposide-induced apoptosis. 

Applications

Protects cells against cold shock, hypoxia and oxidative stress in vitro, as well as CCL4- induced acute liver and chronic liver fibrosis in rodent models.

 

More Information
Alternate Name/Synonyms
NecroX-5; Necrox-5 (methanesulfonate)
SKU
N-1223
CAS #
1383718-29-3
Chemical Name
5-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]-N-(oxan-4-ylmethyl)-2-phenyl-1H-indol-7-amine;methanesulfonic acid
Chemical Formula
C25H31N3O3S2 • 2CH4O3S
Molecular Weight
645.83 Da
Appearance
Light-pink solid
Purity
≥95% (HPLC)
Solubility
Soluble in DMSO (10 mg/mL) or distilled water (10 mg/mL)
Melting Point
N/A
Preparation
N/A
Storage Temp
-20°C
USE
Necrosis Inhibitor-5 selectively blocks oxidative stress-induced necrotic cell death. It does not protect against staurosporine or etoposide-induced apoptosis. It protects cells against cold shock, hypoxia and oxidative stress in vitro, as well as CCl4 -induced acute liver injury and chronic liver fibrosis in rodent models.
Merck Index
N/A
MDL NUMBER
N/A
CHEMACX
N/A
INCHI
N/A
SMILES
N/A
Peptide sequence
N/A
RTECS
N/A
UN #'S
N/A
PACKING GROUP
N/A
HAZARD CLASS
N/A
Handling
Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Certificate of Analysis 1
Certificate of Analysis 2
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
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