Necrostatin-5

SKU
N-1229
  • CAS:337349-54-9
  • Formula:C19H17N3O2S2
  • MW:383.5
  • Appearance:White to off-white Solid
  • Purity:98% (NMR)

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Starting at $46.89

Product Name Qty
Necrostatin-5
20 mg
$82.65
Necrostatin-5
25 mg
$184.26
Necrostatin-5
100 mg
$329.44
Necrostatin-5
5 mg
$46.89
Inhibits non-apoptotic cell deathpathway by inhibition of the death domain receptor-associated adaptor kinase RIP1. Three distinct mechanisms appear to be involved in necroptosis, the alternative active cell death pathway: T-loop dependent inhibition by necrostatin-1; partially T-loop independent inhibition by necrostatin-3 and indirect inhibition of RIP1 by necrostatin-5A.
More Information
Alternate Name/Synonyms
Nec-5
SKU
N-1229
CAS #
337349-54-9
Chemical Name
3-p-MEthoxyphenyl-5,6-tetramethylenothieno[2,3-d] pyrimidin-4-one-2-mercaptoethylcyanide
Chemical Formula
C19H17N3O2S2
Molecular Weight
383.5
Appearance
White to off-white Solid
Purity
98% (NMR)
Solubility
Soluble in DMSO (10mg/ml)
Storage Temp
-20°C
THERAPEUTIC AREA
Not Available
USE
Necrostatin-5 is an inhibitor of necroptosis by indirect inhibition of RIP1 kinase
MDL NUMBER
MFCD01448275
CHEMACX
X1708411-0
INCHI
InChI=1S/C19H17N3O2S2/c1-24-13-8-6-12(7-9-13)22-18(23)16-14-4-2-3-5-15(14)26-17(16)21-19(22)25-11-10-20/h6-9H,2-5,11H2,1H3
SMILES
COc1ccc(cc1)n2c(=O)c3c4c(sc3nc2SCC#N)CCCC4
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Protect from air and light
GHS PICTOGRAMS
Handling Protect from air and light
UN #'S Not Applicable
Packing Group Not Applicable
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