Netropsin Dihydrochloride

SKU
N-4000
  • CAS:18133-22-7
  • Formula:C18H26N10O3•2HCl
  • MW:503.39 Da
  • Appearance:Off-white powder
  • Purity:≥98% by HPLC

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Product Name Qty
Netropsin Dihydrochloride
25 mg
$765.00
Netropsin Dihydrochloride
5 mg
$198.90

Description

Isolated from Streptomyces netropsis, Netropsin Dihydrochloride is a DNA minor groove binding ligand that shows potential antibiotic and antiviral properties. Netropsin Dihydrochloride displays a strong affinity for the AT-rich region in double-stranded DNA, acting as a binding ligand to nucleic acid. Netropsin has been reported to bind to double-stranded DNA at specific base sequences and can block DNA helicase, topoisomerase, and endonuclease. It has also been reported to interfere with transcription factor binding. Netropsin Dihydrochloride binds to double-stranded DNA in a non-intercalative manner when used as an antibiotic.

 Specifications

• EU Number: 634-294-2

More Information
Alternate Name/Synonyms
Netropsin; Congocidin; Sinanomycin
SKU
N-4000
CAS #
18133-22-7
Chemical Name
N-{5-[(3-amino-3-iminopropyl)carbamoyl]-1-methyl-1H-pyrrol-3-yl}-4-{[N-(diaminomethylidene)glycyl]amino}-1-methyl-1H-pyrrole-2-carboxamide
Chemical Formula
C18H26N10O3•2HCl
Molecular Weight
503.39 Da
Appearance
Off-white powder
Purity
≥98% by HPLC
Solubility
Methanol: clear colorless solution at 10 mg/mL
Melting Point
242-245°C
Storage Temp
-10°C to -25°C
THERAPEUTIC AREA
Antibacterial, anti-viral
USE
DNA minor groove binding ligand, potential antibiotic and antiviral properties.
INCHI
QZOOZUGORDEYCC-UHFFFAOYSA-N
SMILES
CN1C=C(C=C1C(=O)NCCC(=O)N)NC(=O)C2=CC(=CN2C)N=C(CN=C(N)N)N.Cl
Handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed.
Certificate of Analysis 1
GHS PICTOGRAMS
Handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed.
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