Netropsin Dihydrochloride

SKU
N-4000
  • CAS:18133-22-7
  • Formula:C18H26N10O3•2HCl
  • MW:503.39 Da
  • Appearance:Off-white powder
  • Purity:≥98% by HPLC

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Product Name Qty
Netropsin Dihydrochloride
25 mg
$765.00
Netropsin Dihydrochloride
5 mg
$198.90

Description

Isolated from Streptomyces netropsis, Netropsin Dihydrochloride is a DNA minor groove binding ligand that shows potential antibiotic and antiviral properties. Netropsin Dihydrochloride displays a strong affinity for the AT-rich region in double-stranded DNA, acting as a binding ligand to nucleic acid. Netropsin has been reported to bind to double-stranded DNA at specific base sequences and can block DNA helicase, topoisomerase, and endonuclease. It has also been reported to interfere with transcription factor binding. Netropsin Dihydrochloride binds to double-stranded DNA in a non-intercalative manner when used as an antibiotic.

 Specifications

• EU Number: 634-294-2

More Information
Alternate Name/Synonyms
Netropsin; Congocidin; Sinanomycin
SKU
N-4000
CAS #
18133-22-7
Chemical Name
N-{5-[(3-amino-3-iminopropyl)carbamoyl]-1-methyl-1H-pyrrol-3-yl}-4-{[N-(diaminomethylidene)glycyl]amino}-1-methyl-1H-pyrrole-2-carboxamide
Chemical Formula
C18H26N10O3•2HCl
Molecular Weight
503.39 Da
Appearance
Off-white powder
Purity
≥98% by HPLC
Solubility
Methanol: clear colorless solution at 10 mg/mL
Melting Point
242-245°C
Storage Temp
-10°C to -25°C
THERAPEUTIC AREA
Antibacterial, anti-viral
USE
DNA minor groove binding ligand, potential antibiotic and antiviral properties.
INCHI
QZOOZUGORDEYCC-UHFFFAOYSA-N
SMILES
CN1C=C(C=C1C(=O)NCCC(=O)N)NC(=O)C2=CC(=CN2C)N=C(CN=C(N)N)N.Cl
Handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed.
GHS PICTOGRAMS
Handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed.
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