NHI-2 | LDHA inhibitor
- Appearance:Off-white solid
- Purity:98% by HPLC NMR (Confirms)
NHI-2 (1269802-97-2) is a selective inhibitor of Lactate Dehydrogenase A (LDHA) - IC50 in vitro = 14.7 μM (NADH), 10.5 μM (Pyruvate). NHI-2 has also shown cellular growth inhibitory effects against pancreatic cancer cells (PANC-1 cells IC50 = 22.2 μM normoxic and 4.0 μM hypoxic; LPC006 cells IC50 = 17.8 μM normoxic and 1.1 μM hypoxic) with increased efficacy in a cancer cells hypoxic environment. LDHA is a key enzyme involved in the Warburg effect and a cancer cells ability to survive in a hypoxic environment.