NHI-2 | LDHA inhibitor

SKU
N-2751
  • CAS:1269802-97-2
  • Formula:C17H12F3NO3
  • MW:335.28
  • Appearance:Off-white solid
  • Purity:98% by HPLC NMR (Confirms)
Product Name Qty
NHI-2, LDHA inhibitor
10 mg
$99.43
NHI-2, LDHA inhibitor
50 mg
$413.38

NHI-2 (1269802-97-2) is a selective inhibitor of Lactate Dehydrogenase A (LDHA) - IC50 in vitro = 14.7 μM (NADH), 10.5 μM (Pyruvate). NHI-2 has also shown cellular growth inhibitory effects against pancreatic cancer cells (PANC-1 cells IC50 = 22.2 μM normoxic and 4.0 μM hypoxic; LPC006 cells IC50 = 17.8 μM normoxic and 1.1 μM hypoxic) with increased efficacy in a cancer cells hypoxic environment. LDHA is a key enzyme involved in the Warburg effect and a cancer cells ability to survive in a hypoxic environment.

More Information
SKU
N-2751
CAS #
1269802-97-2
Chemical Formula
C17H12F3NO3
Molecular Weight
335.28
Appearance
Off-white solid
Purity
98% by HPLC NMR (Confirms)
Solubility
Soluble in DMSO (up to 25 mg/ml).
Stability
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Storage Temp
-20°
Hazard Image
Yes
Certificate of Analysis 1
Promo text for AGS discount
N/A
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