Niclosamide

SKU
N-1219
  • CAS:50-65-7
  • Formula:CHClNO
  • MW:327.12
  • Appearance:Off-white to pale yellow Solid
  • Purity:98% by HPLC

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Product Name Qty
Niclosamide
100 mg
$83.75
Niclosamide
500 mg
$295.94

A STAT3 signaling pathway inhibitor. Niclosamide potently inhibits the activation and transcriptional function of STAT3 and induces cell growth inhibition, apoptosis, and cell cycle arrest of cancer cells with constitutively active STAT3. Also reversibly inhibits mTORC1 signaling and stimulates autophagy in vitro; displays antineoplastic effects in acute myelogenous leukemia (AML) stem cells.

More Information
Alternate Name/Synonyms
5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
SKU
N-1219
CAS #
50-65-7
Chemical Name
5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
Chemical Formula
CHClNO
Molecular Weight
327.12
Appearance
Off-white to pale yellow Solid
Purity
98% by HPLC
Solubility
Soluble in DMSO (10 mM) or Ethanol (25 mM)
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
Niclosamide displays antineoplastic effects in acute myelogenous leukemia (AML) stem cells
MDL NUMBER
MFCD00057597
CHEMACX
X1038740-1
INCHI
InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
SMILES
c1cc(c(cc1[N+](=O)[O-])Cl)NC(=O)c2cc(ccc2O)Cl
Peptide sequence
Not Applicable
RTECS
VN8400000
UN #'S
UN 3077
PACKING GROUP
III
HAZARD CLASS
Not Applicable
Handling
Protect from air and light
Certificate of Analysis 1
Promo text for AGS discount
N/A
GHS PICTOGRAMS
Handling Protect from air and light
UN #'S UN 3077
Packing Group III
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