Niclosamide

SKU
N-1219
  • CAS:50-65-7
  • Formula:C13H8CL2N2O4
  • MW:327.12 Da
  • Appearance:Off-white to pale yellow Solid
  • Purity:≥98% by HPLC

1

0

0

Product Name Qty
Niclosamide
100 mg
$85.43
Niclosamide
500 mg
$301.86

Description

Niclosamide is an anthelmintic used to treatment tapeworm by uncoupling oxidative phosphorylation. It inhibits signal transducer and activator of transcription 3 (STAT3) signaling pathway and arrests cell cycle of cancer cell with constitutively active STAT3. It is exhibited that niclosamide suppresses cell growth and induces apoptosis. This teniacide reversibly inhibits mTORC1 signaling and stimulates autophagy in vitro.

It is reported that niclosamide can inhibit replication of SARS-CoV. Replication of Epstein-Barr virus (EBV) is inhibited by disrupting mTOR activation. In addition, because of its protonophore activity and a capability of acting as a proton carrier, it shows that niclosamide could be used for host-directed antiviral therapies.

 

Application

• Anthelmintic

• Antitumor agent

• Studied as an antiviral agent

 

Reference

“Inhibition of Severe Acute Respiratory Syndrome Coronavirus Replication by Niclosamide”

• “Niclosamide: Beyond an antihelminthic drug”

• “Niclosamide inhibits lytic replication of Epstein-Barr virus by disrupting mTOR activation”

  

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
Niclocide; Bayluscid; Phenasal; Tredemine; Fenasal; Yomesan; Dichlosale; 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
SKU
N-1219
CAS #
50-65-7
Chemical Name
5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
Chemical Formula
C13H8CL2N2O4
Molecular Weight
327.12 Da
Appearance
Off-white to pale yellow Solid
Purity
≥98% by HPLC
Solubility
Soluble in DMSO (10 mM) or Ethanol (25 mM)
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
Niclosamide displays antineoplastic effects in acute myelogenous leukemia (AML) stem cells
MDL NUMBER
MFCD00057597
CHEMACX
X1038740-1
INCHI
InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
SMILES
c1cc(c(cc1[N+](=O)[O-])Cl)NC(=O)c2cc(ccc2O)Cl
Peptide sequence
Not Applicable
RTECS
VN8400000
UN #'S
UN 3077
PACKING GROUP
III
HAZARD CLASS
Not Applicable
Handling
Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. Keep container tightly closed in a dry and well-ventilated place.
Certificate of Analysis 1
GHS PICTOGRAMS
Handling Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. Keep container tightly closed in a dry and well-ventilated place.
UN #'S UN 3077
Packing Group III
To Top