Nilotinib

SKU
N-2364
  • CAS:641571-10-0
  • Formula:C28H22F3N7O
  • MW:529.52
  • Appearance:Off-White Solid
  • Purity:98% by HPLC

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Nilotinib
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 A potent, selective BCR-ABL inhibitor that fits into the ATP-binding site of the BCR-ABL protein with higher affinity than imatinib (Cat. No. 1625-100, 1000). Nilotinib is not only more potent than imatinib against wild-type BCR-ABL (IC< 30 nM), but also significantly active against 32/33 imatinib-resistant BCR-ABL mutants.

More Information
SKU
N-2364
CAS #
641571-10-0
Chemical Formula
C28H22F3N7O
Molecular Weight
529.52
Appearance
Off-White Solid
Purity
98% by HPLC
Solubility
Soluble in DMSO (50 mg/ml)
Stability
N/A
Melting Point
230-242 °C
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
Nilotinib is rationally designed c-Abl and Bcr-Abl kinase inhibitor used to treat certain types of chronic myeloid leukemia
MDL NUMBER
MFCD09833716
CHEMACX
X1616869-9
PubChecm ID
N/A
INCHI
InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37)
SMILES
Cc1ccc(cc1Nc2nccc(n2)c3cccnc3)C(=O)Nc4cc(cc(c4)n5cc(nc5)C)C(F)(F)F
RTECS
CV5581770
Handling
Protect from air and moisture
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Handling Protect from air and moisture
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