Nocodazole, Noc

SKU
N-1177
  • CAS:31430-18-9
  • Formula:C14H11N3O3S
  • MW:301.3
  • Appearance:White powder
  • Purity:≥98%

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Starting at $33.11

Product Name Qty
Nocodazole
10 mg
$60.70
Nocodazole
50 mg
$220.75
Nocodazole
5 mg
$33.11
Nocodazole
25 mg
$121.41

Description

Nocodazole is a synthetic and reversible microtubule inhibitor. It inhibits microtubule polymerization and makes the arrests cells at the G2/M phase. It binds to beta-tubulin and suppresses mitotic spindles

Due to its anti-mitotic properties, it is used to induce apoptosis and for production of mitotic mammalian cells. Arrested cell cycles by the drug can return to normal cell cycles when it is removed.

It has been reported certain concentrations of nocodazole increase p53 and p53-DNA binding and accumulate p21 mRNA in NIH-3T3 fibroblasts.

 

Applications

• Antimitotic agent

• Apoptosis inducer

 

References

“Production of large numbers of mitotic mammalian cells by use of the reversible microtubule inhibitor Nocodazole: Nocodazole accumulated mitotic cells”

“Effects of nocodazole on structures of calf brain tubulin”

“Effects of vinblastine, podophyllotoxin and nocodazole on mitotic spindles. Implications for the role of microtubule dynamics in mitosis”

“Microtubule-active Drugs Taxol, Vinblastine, and Nocodazole Increase the Levels of Transcriptionally Active p53”

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

 

More Information
Alternate Name/Synonyms
R17934; Methyl[5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]carbamate; Noc; Noco
SKU
N-1177
CAS #
31430-18-9
Chemical Name
Methyl[5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]carbamate
Chemical Formula
C14H11N3O3S
Molecular Weight
301.3
Appearance
White powder
Purity
≥98%
Solubility
Soluble in DMSO (10mg/mL), or Dimethyl Formamide. Almost insoluble in water.
Melting Point
200°C
Storage Temp
Room temperature
THERAPEUTIC AREA
Oncological Disorders
USE
A potent tubulin production inhibitor and anti-neoplastic agent
MDL NUMBER
MFCD00005588
CHEMACX
X1013087-3
INCHI
InChI=1S/C14H11N3O3S/c1-20-14(19)17-13-15-9-5-4-8(7-10(9)16-13)12(18)11-3-2-6-21-11/h2-7H,1H3,(H2,15,16,17,19)
SMILES
COC(=O)Nc1[nH]c2ccc(cc2n1)C(=O)c3cccs3
RTECS
DD6521000
Handling
Solutions can be stored at -20°C for up to 3 months.
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
GHS PICTOGRAMS
Handling Solutions can be stored at -20°C for up to 3 months.
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