Nogalamycin

SKU
N-2607
  • CAS:1404-15-5
  • Formula:C39H49NO16
  • MW:787.8 Da
  • Appearance:Red-orange solid
  • Purity:>95% by HPLC
Product Name Qty
Nogalamycin
5 mg
$221.41
Nogalamycin
25 mg
$773.74

Description

Nogalamycin is an unusual anthracycline produced by Streptomyces nogalater, reported by researchers at Upjohn in 1965. Nogalamycin contains two saccharides. The neutral monosaccharide attaches to the D ring, similar to the aminoglycoside moieties of the doxorubicin class, while the second, basic saccharide attaches to the phenolic group on the A ring in the ortho position to form a unique family of hexacyclic anthracyclines.

Nogalamycin is potent anthracycline antibiotic and antitumor agent that interacts with DNA by intercalation, binding with d(CGTACG), d(ATGCAT).


Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
Nogalamycin; U-15167; Nogalamicina;
SKU
N-2607
CAS #
1404-15-5
Chemical Name
methyl (1R,10S,12S,13R,21R,22S,23R,24R)-23-(dimethylamino)-4,8,12,22,24-pentahydroxy-1,12-dimethyl-6,17-dioxo-10-[(2R,3R,4R,5S,6S)-3,4,5-trimethoxy-4,6-dimethyloxan-2-yl]oxy-20,25-dioxahexacyclo[19.3.1.02,19.05,18.07,16.09,14]pentacosa-2,4,7(16),8,14,18-h
Chemical Formula
C39H49NO16
Molecular Weight
787.8 Da
Appearance
Red-orange solid
Purity
>95% by HPLC
Solubility
Soluble in ethanol, methanol, DMF or DMSO.
Storage Temp
-20°C (long term), +4°C (short term)
THERAPEUTIC AREA
Infectious Diseases
USE
Nogalamycin is a potent antibacterial and antitumor agent that interacts with DNA by intercalation.
MDL NUMBER
MFCD00083442
PubChecm ID
4526
INCHI
InChI=1S/C39H49NO16/c1-14-32(49-7)39(4,52-10)33(50-8)36(53-14)54-19-13-37(2,48)24(34(47)51-9)15-11-16-21(27(43)20(15)19)28(44)22-18(41)12-17-30(23(22)26(16)42)55-35-29(45)25(40(5)6)31(46)38(17,3)56-35/h11-12,14,19,24-25,29,31-33,35-36,41,43,45-46,48H,13H2,1-10H3/t14-,19-,24-,25-,29-,31+,32-,33-,35+,36-,37-,38+,39+/m0/s1
SMILES
C[C@H]1[C@@H]([C@@]([C@H]([C@@H](O1)O[C@H]2C[C@]([C@@H](c3c2c(c4c(c3)C(=O)c5c(c(cc6c5O[C@H]7[C@H]([C@@H]([C@H]([C@@]6(O7)C)O)N(C)C)O)O)C4=O)O)C(=O)OC)(C)O)OC)(C)OC)OC
Handling
Handle in accordance with good industrial hygiene and safety practice.
GHS PICTOGRAMS
HandlingHandle in accordance with good industrial hygiene and safety practice.
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