Nonactin

SKU
N-1155
  • CAS:6833-84-7
  • Formula:C40H64O12
  • MW:736.93 Da
  • Appearance:White powder
  • Purity:≥95%

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Product Name Qty
Nonactin, Macrotetrolide antibiotic
10 mg
$114.99
Nonactin, Macrotetrolide antibiotic
50 mg
$249.99

Description:

Nonactin is a cyclic ionophore that belongs to the macrotetrolide antibiotic family. The process of nonactin is to bind a metal ionophore and transport it across the cell membrane. This is possible due to the compounds conformational flexibility and hydrophobic exterior. Nonactin also inhibits the processing of cytoplasmic precursor proteins destined for the mitochondria.

Applications:

• Used to inhibit the production of gene transcription 
• Used to facilitate the movement of monovalent cations through natural and artificial membranes
• Used as an ammonium ionophore for ammonium ion determination in a potentiometric electrode for biosensor construction

More Information
Alternate Name/Synonyms
Werramycin-A; Ammonium ionophore; Ammonium ionophore I; Macrotetrolide analogue
SKU
N-1155
CAS #
6833-84-7
Chemical Name
(1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-2,5,11,14,20,23,29,32-octamethyl-4,13,22,31,37,38,39,40-octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone
Chemical Formula
C40H64O12
Molecular Weight
736.93 Da
Appearance
White powder
Purity
≥95%
Solubility
soluble in CH2Cl2/DMSO: Clear and colorless solution at 10 mg/mL.
Melting Point
146°C
Preparation
N/A
Storage Temp
-20°C
THERAPEUTIC AREA
Not Available
USE
Nonactin is a macrotetrolide that forms complexes with alkali cations, such as potassium and sodium. It has been reported to inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria. Nonactin is an uncoupler of oxidative phosphorylation. It has been recorded to function by binding a metal ionophore and transporting it across cell membranes for release. The compound can functionally perform this transport due to its conformational flexibility and hydrophobic exterior. The compound forms a natural diastereomer which is required for its antibacterial and binding capacities.
Merck Index
N/A
MDL NUMBER
MFCD03267283
CHEMACX
X1009767-7
PubChecm ID
72519
INCHI
InChI=1S/C40H64O12/c1-21-17-29-9-13-34(49-29)26(6)38(42)46-23(3)19-31-11-15-36(51-31)28(8)40(44)48-24(4)20-32-12-16-35(52-32)27(7)39(43)47-22(2)18-30-10-14-33(50-30)25(5)37(41)45-21/h21-36H,9-20H2,1-8H3/t21-,22+,23+,24-,25-,26+,27+,28-,29-,30+,31+,32-,33-,34+,35+,36-
SMILES
C[C@@H]1C[C@H]2CC[C@H](O2)[C@@H](C(=O)O[C@H](C[C@@H]3CC[C@@H](O3)[C@H](C(=O)O[C@@H](C[C@H]4CC[C@H](O4)[C@@H](C(=O)O[C@H](C[C@@H]5CC[C@@H](O5)[C@H](C(=O)O1)C)C)C)C)C)C)C
RTECS
RH1685000
Handling
Use only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.
msds 1
/media/upload/pdf/N-1155, Nonactin, SDS, diamond format.pdf
Certificate of Analysis 1
/media/upload/pdf/N-1155, J1157C.pdf
Certificate of Analysis 2
/media/upload/pdf/N-1155, J1157B.pdf
Certificate of Analysis 3
/media/upload/pdf/N-1155, J1157A.pdf
Handling Use only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.
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