Nosiheptide

SKU
N-2611
  • CAS:56377-79-8
  • Formula:C51H43N13O12S6
  • MW:1222.4
  • Appearance:Yellow solid
  • Purity:>95% by HPLC
Product Name Qty
Nosiheptide
1 mg
$113.02
Nosiheptide
5 mg
$396.19

*Please inquire the availability for this product. Nosiheptide is a bicyclic thiopeptide antibiotic produced by several species of actinomycetes, notably Streptomyces, first reported by Japanese researchers in 1970. Unlike other bicyclic thiopeptides such as thiostrepton, the second macrocyclic ring is linked by relatively fragile lactone and thiolactone bridges to the core cyclic peptide. Nosiheptide has broad spectrum antibacterial activity, and has recently demonstrated a prolonged post-antibiotic effect in both nosocomial and community-acquired MRSA compared with vancomycin. Despite its long history in animal health, nosiheptide has not been extensively studied and is regarded as a "lost antibiotic" largely escaping intensive investigation for human application.

More Information
Alternate Name/Synonyms
Nosiheptine, Multhiomycin, Primofax, RP 9671
SKU
N-2611
CAS #
56377-79-8
Chemical Formula
C51H43N13O12S6
Molecular Weight
1222.4
Appearance
Yellow solid
Purity
>95% by HPLC
Storage Temp
-20°C
THERAPEUTIC AREA
Infectious Diseases
USE
Nosiheptide has broad spectrum antibacterial activity
MDL NUMBER
MFCD00867479
INCHI
InChI=1S/C51H43N13O12S6/c1-5-23-46-60-28(14-79-46)41(70)56-25-10-33(67)50(74)76-11-21-7-6-8-24-34(21)18(2)35(54-24)51(75)82-17-31(57-42(71)29-15-80-47(25)61-29)48-58-26(12-78-48)37-22(45-59-30(13-77-45)43(72)64-36(20(4)65)44(73)55-23)9-32(66)38(63-37)49-62-27(16-81-49)40(69)53-19(3)39(52)68/h5-9,12-16,20,25,31,33,36,54,65-67H,3,10-11,17H2,1-2,4H3,(H2,52,68)(H,53,69)(H,55,73)(H,56,70)(H,57,71)(H,64,72)/b23-5-
SMILES
C/C=C\1/c2nc(cs2)C(=O)NC3CC(C(=O)OCc4cccc5c4c(c([nH]5)C(=O)SCC(c6nc(cs6)-c7c(cc(c(n7)c8nc(cs8)C(=O)NC(=C)C(=O)N)O)-c9nc(cs9)C(=O)NC(C(=O)N1)C(C)O)NC(=O)c1csc3n1)C)O
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