SDS
CofA
Description
Novobiocin Sodium Salt is an inhibitor of HSP90. Novobiocin interacts with the C-terminal ATP-binding domain of HSP90, unlike 17-AAG, geldanamycin, herbimycin A, or radicicol, which all bind to the N-terminal ATP-binding site of HSP90. Novobiocin is also useful in the production of positively supercoiled plasma DNA, targeting the nucleotide-binding site of gyrase B.
More Information
Alternate Name/Synonyms
Novobiocin sodium; Cathomycin sodium
SKU
N-1180
CAS #
1476-53-5
Chemical Name
sodium;4-[[7-(4-carbamoyloxy-3-hydroxy-5-methoxy-6,6-dimethyloxan-2-yl)oxy-4-hydroxy-8-methyl-2-oxochromen-3-yl]carbamoyl]-2-(3-methylbut-2-enyl)phenolate
Chemical Formula
C31H35N2NaO11
Molecular Weight
634.61 Da
Appearance
White to yellow powder
Purity
≥90%
Solubility
Water
Storage Temp
2-8°C
Merck Index
14: 6722
Handling
Wear personal protective equipment. Ensure adequate ventilation. Avoid contact with skin, eyes and clothing. Avoid ingestion and inhalation. Avoid dust formation
Certificate of Analysis 1
| GHS PICTOGRAMS |  |
|---|---|
| Handling | Wear personal protective equipment. Ensure adequate ventilation. Avoid contact with skin, eyes and clothing. Avoid ingestion and inhalation. Avoid dust formation |
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