NSC-146109 Hydrochloride

SKU
N-1215
  • CAS:59474-01-0
  • Formula:C17H16N2S.HCl
  • MW:316.85
  • Appearance:Yellow Solid
  • Purity:98%
Product Name Qty
NSC-146109.HCl
5 mg
$148.07
Cell-permeable. A p53 activator. It strongly activates p53 while selectively inhibiting growth of transformed cells without inducing genotoxicity. It promotes breast cancer cells to undergo apoptosis through activating p53 and inducing expression of proapoptotic genes. Recently, it has been found that activation of p53 by this small molecule is achieved through inhibition of MDMX expression. XI-011 repressed the MDMX promoter, resulting in down-regulation of MDMX mRNA level in MCF-7 cell.
More Information
Alternate Name/Synonyms
XI-011
SKU
N-1215
CAS #
59474-01-0
Chemical Name
(10-Methyl-9-anthracenyl) methyl carbamimidothioic acid ester hydrochloride
Chemical Formula
C17H16N2S.HCl
Molecular Weight
316.85
Appearance
Yellow Solid
Purity
98%
Solubility
Soluble in DMSO (100 mM) or EtOH (10 mM)
Stability
N/A
Storage Temp
Room Temp
THERAPEUTIC AREA
Oncological Disorders
USE
NSC 146109 hydrochloride is a cell-permeable, genotype-selective antitumor agent that activates p53-dependent transcription
MDL NUMBER
MFCD09878281
CHEMACX
X1486529-7
INCHI
InChI=1S/C17H16N2S.ClH/c1-11-12-6-2-4-8-14(12)16(10-20-17(18)19)15-9-5-3-7-13(11)15;/h2-9H,10H2,1H3,(H3,18,19);1H
SMILES
[H]/N=C(\[NH3+])/SCc1c2ccccc2c(c3c1cccc3)C.[Cl-]
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Do not take internally. Wear gloves an mask when handling the product.Avoid contact by all modes of exposure.
Certificate of Analysis 1
Promo text for AGS discount
N/A
GHS PICTOGRAMS
Handling Do not take internally. Wear gloves an mask when handling the product.Avoid contact by all modes of exposure.
UN #'S Not Applicable
Packing Group Not Applicable
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