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Cell-permeable. A p53 activator. It strongly activates p53 while selectively inhibiting growth of transformed cells without inducing genotoxicity. It promotes breast cancer cells to undergo apoptosis through activating p53 and inducing expression of proapoptotic genes. Recently, it has been found that activation of p53 by this small molecule is achieved through inhibition of MDMX expression. XI-011 repressed the MDMX promoter, resulting in down-regulation of MDMX mRNA level in MCF-7 cell.
(10-Methyl-9-anthracenyl) methyl carbamimidothioic acid ester hydrochloride
Soluble in DMSO (100 mM) or EtOH (10 mM)
NSC 146109 hydrochloride is a cell-permeable, genotype-selective antitumor agent that activates p53-dependent transcription
Do not take internally. Wear gloves an mask when handling the product.Avoid contact by all modes of exposure.
Certificate of Analysis 1
|Handling||Do not take internally. Wear gloves an mask when handling the product.Avoid contact by all modes of exposure.|
|UN #'S||Not Applicable|
|Packing Group||Not Applicable|