NU6140

SKU
N-1175
  • CAS:444723-13-1
  • Formula:C23H30N6O2
  • MW:422.5
  • Appearance:White to off-white Solid
  • Purity:95% by HPLC
Product Name Qty
NU6140
5 mg
$313.24
Highly cell permeable purine compound that acts as a selective and ATP-competitive inhibitor of Cdks (IC=6.6M, 0.41M, 5.5M, 15M and 3.9M for Cdk1/cyclin B, Cdk2/cyclin A, Cdk4/cyclin D, Cdk5/p25 and Cdk7/cyclin H) and displays anti-cancer properties. Causes cell cycle arrest at the G2/M phase and induces apoptosis by activating caspases and downregulating survivin.
More Information
SKU
N-1175
CAS #
444723-13-1
Chemical Name
4-(6-Cyclohexylmethoxy-9H-purin-2-ylamino)-N,N-diethylbenzamide
Chemical Formula
C23H30N6O2
Molecular Weight
422.5
Appearance
White to off-white Solid
Purity
95% by HPLC
Solubility
Soluble in DMSO (10mg/ml).
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
Cdk2 Inhibitor IV, NU6140 is a highly cell-permeable purine compound that displays anticancer properties and acts as a selective and ATP-competitive inhibitor of Cdks
MDL NUMBER
MFCD09264153
CHEMACX
X2273892-7
INCHI
InChI=1S/C23H30N6O2/c1-3-29(4-2)22(30)17-10-12-18(13-11-17)26-23-27-20-19(24-15-25-20)21(28-23)31-14-16-8-6-5-7-9-16/h10-13,15-16H,3-9,14H2,1-2H3,(H2,24,25,26,27,28)
SMILES
CCN(CC)C(=O)C1=CC=C(C=C1)NC2=NC3=C(C(=N2)OCC4CCCCC4)N=CN3
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Store in Tightly Sealed Vial Packaged under inert gas. Protect from Light Warning.Toxic. May be Carcinogenic.
Handling Store in Tightly Sealed Vial Packaged under inert gas. Protect from Light Warning.Toxic. May be Carcinogenic.
UN #'S Not Applicable
Packing Group Not Applicable
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