SDS
CofA
Highly cell permeable purine compound that acts as a selective and ATP-competitive inhibitor of Cdks (IC=6.6M, 0.41M, 5.5M, 15M and 3.9M for Cdk1/cyclin B, Cdk2/cyclin A, Cdk4/cyclin D, Cdk5/p25 and Cdk7/cyclin H) and displays anti-cancer properties. Causes cell cycle arrest at the G2/M phase and induces apoptosis by activating caspases and downregulating survivin.
More Information
SKU
N-1175
CAS #
444723-13-1
Chemical Name
4-(6-Cyclohexylmethoxy-9H-purin-2-ylamino)-N,N-diethylbenzamide
Chemical Formula
C23H30N6O2
Molecular Weight
422.5
Appearance
White to off-white Solid
Purity
95% by HPLC
Solubility
Soluble in DMSO (10mg/ml).
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
Cdk2 Inhibitor IV, NU6140 is a highly cell-permeable purine compound that displays anticancer properties and acts as a selective and ATP-competitive inhibitor of Cdks
MDL NUMBER
MFCD09264153
CHEMACX
X2273892-7
INCHI
InChI=1S/C23H30N6O2/c1-3-29(4-2)22(30)17-10-12-18(13-11-17)26-23-27-20-19(24-15-25-20)21(28-23)31-14-16-8-6-5-7-9-16/h10-13,15-16H,3-9,14H2,1-2H3,(H2,24,25,26,27,28)
SMILES
CCN(CC)C(=O)C1=CC=C(C=C1)NC2=NC3=C(C(=N2)OCC4CCCCC4)N=CN3
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Store in Tightly Sealed Vial Packaged under inert gas. Protect from Light Warning.Toxic. May be Carcinogenic.
| Handling | Store in Tightly Sealed Vial Packaged under inert gas. Protect from Light Warning.Toxic. May be Carcinogenic. |
|---|---|
| UN #'S | Not Applicable |
| Packing Group | Not Applicable |
