Nutlin-3

SKU
N-2367
  • CAS:548472-68-0
  • Formula:C30H30Cl2N4O4
  • MW:581.49
  • Appearance:White to off-white Solid
  • Purity:98% by HPLC

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Product Name Qty
Nutlin-3
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 Cell-permeable. Nutlin-3 is a Mdm2 (mouse double minute 2) antagonist (IC= 90 nM for Nutlin-3a and 13.6 M for Nutlin-3b), p53 pathway activator, and apoptosis inducer.

More Information
SKU
N-2367
CAS #
548472-68-0
Chemical Formula
C30H30Cl2N4O4
Molecular Weight
581.49
Appearance
White to off-white Solid
Purity
98% by HPLC
Solubility
Soluble in DMSO (~20 mg/ml)
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
Disrupts MDM2-p53 interaction, inducing apoptosis
MDL NUMBER
MFCD07784509
CHEMACX
X1463065-0
INCHI
InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)
SMILES
CC(C)Oc1cc(ccc1C2=NC(C(N2C(=O)N3CCNC(=O)C3)c4ccc(cc4)Cl)c5ccc(cc5)Cl)OC
Handling
Protect from air and light
Handling Protect from air and light
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