Oxidative Stress is caused by an imbalance between the production of reactive oxygen and a biological system's ability to readily detoxify the reactive intermediates. This reducing environment is preserved by enzymes that maintain the reduced state through a constant input of metabolic energy. Disturbances in this normal redox state can cause toxic effects that can damage proteins and lipids. Radicicol is an antifungal antibiotic which acts as a Hsp90-specific 17-AAG is an ansamycin antibiotic which binds to Hsp90 (Heat Shock Protein 90) and alters it function. Hsp90 proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, and oncogenesis.
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