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Oligomycin A is an inhibitor of ATP synthase. In oxidative phosphorylation research, it is used to prevent state 3 (phosphorylating) respiration. Oligomycin A inhibits ATP synthase by blocking its proton channel (Fo subunit), which is necessary for oxidative phosphorylation of ADP to ATP (energy production).
The inhibition of ATP synthesis by oligomycin A will significantly reduce electron flow through the electron transport chain however, electron flow is not stopped completely due to a process known as proton leak or mitochondrial coupling. This process occurs due to the facilitated diffusion of protons into the mitochondrial matrix through an uncoupling protein such as thermogenin, or UCP1.
Oligomycin A stimulates lysosome acidification due to shunting of membrane potential. Induces apoptosis in a variety of cell types. Oligomycin A also induces autophagy in the IPLB-LdFB insect cell line.
Isolated from Streptomyces sp.
Not for human therapeutic use or for medicinal purposes. For research applications only.
|Handling||Warning: Toxic. May be Carcinogenic. May be Teratogenic. Protect from light.|