Ostreogrycin A

SKU
O-2561
  • CAS:21411-53-0
  • Formula:C28H35N3O7
  • MW:525.6
  • Appearance:White solid
  • Purity:>99% by HPLC
Product Name Qty
Ostreogrycin A
5 mg
$363.56
Ostreogrycin A
25 mg
$1,272.47
*Please inquire the availability for this product. Ostreogrycin A (virginiamycin M1, streptogramin A) is the major component of the virginiamycin complex. In the 1950s this complex was independently discovered so many times that the literature became highly confusing. Ostreogrycin A is a macrocyclic lactone antibiotic that acts synergistically with the structurally unrelated cyclic depsipeptides, virginiamycin B (ostreogrycin B, streptogramin B) and virginiamycin S, to inhibit peptide elongation. This is achieved by blocking formation of a peptide bond between the growing peptide chain (peptidyl-tRNA) linked to the 50S ribosome and aminoacyl-tRNA. Ostreogrycin A is highly active against Gram positive bacteria, particularly MRSA.
More Information
Alternate Name/Synonyms
Mikamycin A, Pristinamycin IIA, Stephylomycin M1, Streptogramin A, Syncothrecin A, Synergistin A1, Virginiamycin M1, Vernamycin A, 14752-2, E129A, PA 114A, 1745Z3A, 547C, Factor M
SKU
O-2561
CAS #
21411-53-0
Chemical Formula
C28H35N3O7
Molecular Weight
525.6
Appearance
White solid
Purity
>99% by HPLC
Solubility
Soluble in water (partly), ethanol (4%), methanol (4%), DMF, and DMSO
Melting Point
165-167.2 °C
Storage Temp
-20°C
THERAPEUTIC AREA
Infectious Diseases
USE
Ostreogrycin A has highly active against Gram positive bacteria
MDL NUMBER
MFCD00869411
INCHI
InChI=1S/C28H35N3O7/c1-17(2)26-19(4)9-10-24(34)29-11-5-7-18(3)13-20(32)14-21(33)15-25-30-22(16-37-25)27(35)31-12-6-8-23(31)28(36)38-26/h5,7-10,13,16-17,19-20,26,32H,6,11-12,14-15H2,1-4H3,(H,29,34)/b7-5+,10-9+,18-13+/t19-,20-,26-/m1/s1
SMILES
C[C@@H]1/C=C/C(=O)NC/C=C/C(=C/[C@H](CC(=O)Cc2nc(co2)C(=O)N3CCC=C3C(=O)O[C@@H]1C(C)C)O)/C
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