P32/98, DPP IV Inhibitor (CD26)

SKU
P-1685
  • CAS:136259-20-6
  • Formula:C9H18N2OS • 0.5C4H404
  • MW:260.4 Da
  • Appearance:White powder
  • Purity:>98% (TLC)

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Product Name Qty
P32/98, DPP IV Inhibitor
50 mg
$582.17
P32/98, DPP IV Inhibitor
10 mg
$122.88

Description

P32/98 is a cell-permeable, potent and selective inhibitor of dipeptidyl peptidase IV (DPPIV) (Ki=130nM). May be used in cell culture (1-10 mM) or in vivo (10 mg/Kg orally).  It has been hypothesized that chronic DPPIV inhibitor treatment of diabetic animals, improves glucose tolerance, enhances β-cell glucose responsiveness, replication, and turnover, and results in sustained improvements in β-cell function.

As previously stated, DPP IV inhibitors are a new class of anti-diabetic drugs. However, DPP IV metabolizes to at least 24 endogenous substrates, the pharmacological consequences of inhibiting the metabolism of most of these substrates is unknown. Research studies have shown that DPP IV is expressed in the renal microcirculation and inhibition of this ectoenzyme causes arterial PYY1–36 to more effectively enhance angiotensin II-induced renal vasoconstriction in genetically susceptible kidneys.

 

Application:

P32/98 is a specific, competitive transition state substrate analog inhibitor of dipeptidyl peptidase IV (DPP-IV, DPIV, CD26, CD-26). Useful in diabetes research, as well as, protein preservation studies & transport.

 

More Information
Alternate Name/Synonyms
Isoleucyl thiazolidide
SKU
P-1685
CAS #
136259-20-6
Chemical Name
(2S, 3S)-2-Amino-3 –methyl-1-(thiazolidin-3-yl)pentan-1-one hemi-fumarate
Chemical Formula
C9H18N2OS • 0.5C4H404
Molecular Weight
260.4 Da
Appearance
White powder
Purity
>98% (TLC)
Solubility
May be dissolved in H2O (20 mg/mL) or DMSO (25 mg/mL).
Melting Point
N/A
Preparation
N/A
Storage Temp
Store desiccated at -20°C
THERAPEUTIC AREA
Endocrine Disorders
USE
P32/98 is a specific, competitive transition-state substrate analog inhibitor of dipeptidyl peptidase IV (DPIV, DPPIV, and CD26). In obese Zucker and lean rats the inhibition of CD26's ability to hydrolyze Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide (GLP-1) lead to an increased secretion of insulin, especially in the obsese Rat, making P32/98 an important tool in diabetic research. P32/98 has also been shown to augment YY1-36's ability to enhance renovascular responses to angiotensin II in spontaneoulsy hypertensive rats. Due to CD26's effect on upregultating lymphocyte proliferation P32/98 has been demonstrated to decrease the lymphocyte proliferation.
Merck Index
N/A
RTECS
N/A
Handling
Use only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
Handling Use only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.
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