PAC-1

SKU
P-2377
  • CAS:315183-21-2
  • Formula:C23H28N4O2
  • MW:392.49
  • Appearance:White Solid
  • Purity:95% by HPLC
Product Name Qty
PAC-1
10 mg
$108.21
Procaspase-activating compound 1 (PAC-1) directly activates procaspase-3 to caspase-3, a transformation that allows induction of apoptosis even in cells that have defective apoptotic machinery. In cancer cells, PAC-1 had an ICvalue of 3 nM for induction of cell death, whereas in cells from adjacent normal tissue had ICvalues of 3.2-8.5 M.
More Information
Alternate Name/Synonyms
2-[[2-Hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide 4-(phenylmethyl)-1-piperazineacetic acid
SKU
P-2377
CAS #
315183-21-2
Chemical Name
2-[[2-Hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide 4-(phenylmethyl)-1-piperazineacetic acid
Chemical Formula
C23H28N4O2
Molecular Weight
392.49
Appearance
White Solid
Purity
95% by HPLC
Solubility
Soluble in DMSO
Melting Point
250.41 °C
Storage Temp
+4°C
THERAPEUTIC AREA
Oncological Disorders
USE
PAC 1 is a procaspase-activating compound, which in turn produces caspase-3
MDL NUMBER
MFCD03302441
CHEMACX
X1579428-6
INCHI
InChI=1S/C23H28N4O2/c1-2-7-20-10-6-11-21(23(20)29)16-24-25-22(28)18-27-14-12-26(13-15-27)17-19-8-4-3-5-9-19/h2-6,8-11,16,29H,1,7,12-15,17-18H2,(H,25,28)/b24-16-
SMILES
C=CCc1cccc(c1O)/C=NNC(=O)CN2CCN(CC2)Cc3ccccc3
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
UN 3077
PACKING GROUP
III
HAZARD CLASS
Not Applicable
Handling
Protect from air and light
GHS PICTOGRAMS
HandlingProtect from air and light
UN #'SUN 3077
Packing GroupIII
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