Panobinostat

SKU
P-2380
  • CAS:404950-80-7
  • Formula:C21H23N3O2
  • MW:349.43
  • Appearance:Crystalline Solid
  • Purity:99% by HPLC
Product Name Qty
Panobinostat
25 mg
$1,133.37
Panobinostat
1 mg
$119.60
Panobinostat
5 mg
$370.19

Panobinostat (LBH589) is a highly potent inhibitor of both histone deacetylase 1 (HDAC1) activity and tumour cell proliferation in vitro. The ICvalues of HDAC isozymes HDAC1-IP Ac-H4, HDAC8, MALunselective, B61HDAC1 and B12HDAC6 are 0.230.06, 28329, 754, 475 and 8912 nM, respectively. And to A2780 proliferation, ICvalue is 4.61.8 nM.

More Information
Alternate Name/Synonyms
LBH589, LBN-589, NVP-LBH590
SKU
P-2380
CAS #
404950-80-7
Chemical Name
(E)-N-HYDROXY-3-[4-[[2-(2-METHYL-1H-INDOL-3-YL)ETHYLAMINO]METHYL]PHENYL]PROP-2-ENAMIDE
Chemical Formula
C21H23N3O2
Molecular Weight
349.43
Appearance
Crystalline Solid
Purity
99% by HPLC
Solubility
DMSO
Melting Point
115 °C
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
An HDAC inhibitor reported to inhibit human multiple myeloma cell lines
MDL NUMBER
MFCD09833242
CHEMACX
X1612494-6
INCHI
InChI=1S/C21H23N3O2/c1-15-18(19-4-2-3-5-20(19)23-15)12-13-22-14-17-8-6-16(7-9-17)10-11-21(25)24-26/h2-11,22-23,26H,12-14H2,1H3,(H,24,25)/b11-10+
SMILES
CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)/C=C/C(=O)NO
RTECS
UC6378000
Handling
Protect from air and moisture
GHS PICTOGRAMS
Handling Protect from air and moisture
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