Paromomycin Sulfate

SKU
P-2823
  • CAS:1263-89-4
  • Formula:C23H45N5O14 • H2SO4
  • MW:615.6
  • Appearance:White to white off powder
Product Name Qty
Paromomycin Sulfate
25 g
$304.97
Paromomycin Sulfate
5 g
$101.18

Description

Paromomycin sulfate is an aminoglycoside antibiotic effective against Gram-negative and Gram-positive bacteria, protozoa and cestodes. The antibiotic has a similar effect as neomycin.

Paromomycin binds to a highly conserved sequence, the A site, of the 16S rRNA of the 30S ribosomal subunit in bacteria. It induces a conformational change and thus interrupts translation and synthesis of protein and leads to cell death.

It has antiprotozoal properties and treats parasitic diseases such as Leishmaniasis.

 

Applications

• Aminoglycoside antibiotic

• Protein synthesis inhibitor

• Anti-parasitic

• Selective agent of oat transformation

 

Specifications

• Assay: ≥ 675 U/mg

• Loss on Drying: ≤ 5.0%

• pH 3.0% Solution at 25°C: 5.0 - 7.5

• Specific Optical Rotation: +50.0 - +55.0°C

 

References

“Paromomycin”

“Use of paromomycin as a selective agent for oat transformation”

“Ribosomal RNA Recognition by Aminoglycoside Antibiotics”

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
Paromomycin Sulphate; Aminosidine sulfate; Aminosidin sulfate; Aminosidine sulphate; Aminoxidin; Farmiglucin; Farminosidin; Humagel
SKU
P-2823
CAS #
1263-89-4
Chemical Name
(2S,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(2R,3S,4R,5S)-5-[(1R,2R,3S,5R,6S)-3,5-diamino-2-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol;sulfuric ac
Chemical Formula
C23H45N5O14 • H2SO4
Molecular Weight
615.6
Appearance
White to white off powder
Solubility
Water
Storage Temp
Room temperature
THERAPEUTIC AREA
Antibiotic
USE
Gram negative- and Gram positive antibiotics and Anti-protozoal drug
Handling
Use in a chemical fume hood, with air supplied by an independent system. Avoid inhalation, contact with eyes, skin and clothing. Avoid the formation of dust and aerosols. Use in a well-ventilated area. Keep away from sources of ignition. Avoid prolonged or repeated exposure.
Certificate of Analysis 1
Certificate of Analysis 2
GHS PICTOGRAMS
HandlingUse in a chemical fume hood, with air supplied by an independent system. Avoid inhalation, contact with eyes, skin and clothing. Avoid the formation of dust and aerosols. Use in a well-ventilated area. Keep away from sources of ignition. Avoid prolonged or repeated exposure.
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