SDS
CofA
Description
Paromomycin sulfate is an aminoglycoside antibiotic effective against Gram-negative and Gram-positive bacteria, protozoa and cestodes. The antibiotic has a similar effect as neomycin.
Paromomycin binds to a highly conserved sequence, the A site, of the 16S rRNA of the 30S ribosomal subunit in bacteria. It induces a conformational change and thus interrupts translation and synthesis of protein and leads to cell death.
It has antiprotozoal properties and treats parasitic diseases such as Leishmaniasis.
Applications
• Aminoglycoside antibiotic
• Protein synthesis inhibitor
• Anti-parasitic
• Selective agent of oat transformation
Specifications
• Assay: ≥ 675 U/mg
• Loss on Drying: ≤ 5.0%
• pH 3.0% Solution at 25°C: 5.0 - 7.5
• Specific Optical Rotation: +50.0 - +55.0°C
References
• “Use of paromomycin as a selective agent for oat transformation”
• “Ribosomal RNA Recognition by Aminoglycoside Antibiotics”
Not for human therapeutic use or for medicinal purposes. For research applications only.
| GHS PICTOGRAMS |   |
|---|---|
| Handling | Use in a chemical fume hood, with air supplied by an independent system. Avoid inhalation, contact with eyes, skin and clothing. Avoid the formation of dust and aerosols. Use in a well-ventilated area. Keep away from sources of ignition. Avoid prolonged or repeated exposure. |
