Parthenolide

SKU
P-1233
  • CAS:20554-84-1
  • Formula:C15H20O3
  • MW:248.3
  • Appearance:White Solid
  • Purity:98%

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Product Name Qty
Parthenolide
250 mg
$217.76
Parthenolide
50 mg
$77.06
Inhibits activation of MAP kinase. Also anti-inflammatory and anti-secretory.Parthenolide Inhibits TNF/IL-1 or TNFInduced Production of IL-81.Parthenolide Inhibits I B Kinase, NF- B Activation, and Inflammatory Response in Cystic Fibrosis Cells and Mice. NF-B inhibitor parthenolide and the COX-2 inhibitor NS398 each inhibited hepatocellular carcinoma growth in a concentration-dependent manner. In addition, the combination of parthenolide and NS398 reduced the concentration of NS398 required to inhibit hepatocellular carcinoma growth.Parthenolide Cooperates with NS398 to Inhibit Growth of Human Hepatocellular Carcinoma Cells through Effects on Apoptosis and G-G Cell Cycle Arrest. Nuclear Factor- B Inhibition by Parthenolide Potentiates the Efficacy of Taxol in NonSmall Cell Lung Cancer.The NF-B inhibitor, parthenolide, may enhance chemosensitivity to paclitaxel in the treatment of patients with gastric cancer. Enhances Response to Chemotherapy in Gastric Cancer. Parthenolide promotes the ubiquitination of MDM2 and activates p53 cellular functions.
More Information
SKU
P-1233
CAS #
20554-84-1
Chemical Name
4,5-ALPHA-EPOXY-6BETA-HYDROXYGERMACRA-1(10),11(13)-DIEN-12-OIC ACID-GAMMA-LACTONE
Chemical Formula
C15H20O3
Molecular Weight
248.3
Appearance
White Solid
Purity
98%
Solubility
Soluble in Ethyl Acetate and DMSO
Melting Point
118-120‚°C
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
Parthenolide shows anticancer activity against human melanoma cells
MDL NUMBER
MFCD00134592
CHEMACX
X1017283-1
INCHI
InChI=1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3/b9-5-
SMILES
C/C/1=C/CCC2(C(O2)C3C(CC1)C(=C)C(=O)O3)C
Peptide sequence
Not Applicable
RTECS
LY4220000
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Store in Tightly Sealed Vial
Citations
MOLECULAR AND CELLULAR PATHOBIOLOGY: RSF1 Is a Positive Regulator of NF-{kappa}B–Induced Gene Expression Required for Ovarian Cancer Chemoresistance Yeong-In Yang, Ji-Hye Ahn, Kyung-Tae Lee, Ie-Ming Shih, and Jung-Hye Choi Cancer Res., Apr 2014; 74: 2258 - 2269.
Citations_Hyperlink
http://cancerres.aacrjournals.org/content/74/8/2258.full.pdf+html
Certificate of Analysis 1
Handling Store in Tightly Sealed Vial
UN #'S Not Applicable
Packing Group Not Applicable
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