Patulin

SKU
P-1097
  • CAS:149-29-1
  • Formula:C7H6O4
  • MW:154.1 Da
  • Appearance:White crystals
  • Purity:≥98%

2

0

0

Product Name Qty
Patulin
5 mg
$116.16
Patulin
10 mg
$195.43

Description

Patulin is a type of mycotoxin that is created by different kinds of molds, including Penicillium and Aspergillus. This mycotoxin is often found in apples. It has the appearance of white crystals. It was at one time used as an antibiotic against both Gram-negative and Gram-positive bacteria, but is no longer used this way. Patulin not only acts as a potassium uptake inhibitor, but also as an ion flux inducer across cell membranes. These actions contribute to protein crosslinking. Apoptosis inducer via ROS-mediated endoplasmic reticulum stress pathway.

It is soluble in DMSO and becomes a colorless, clear solution at 10 mg/mL. Patulin can be highly toxic and must be tightly sealed and stored away from light.

 

Applications

• Patulin can be used to inhibit potassium uptake
• Used to examine potential Patulin contamination that can occur in bottled wine
• Molecular cloning
• Induction ion flux across cell membranes
• Study of DNA damage by Patulin in E. coli

 

More Information
Alternate Name/Synonyms
Clavacin; Expansin; Clairformin; Penatin; Mycosin
SKU
P-1097
CAS #
149-29-1
Chemical Name
4-hydroxy-4,6-dihydrofuro[3,2-c]pyran-2-one
Chemical Formula
C7H6O4
Molecular Weight
154.1 Da
Appearance
White crystals
Purity
≥98%
Solubility
Soluble in DMSO, clear colorless solution at 10 mg/mL
Melting Point
112°C
Preparation
N/A
Storage Temp
-20°C, desiccated
THERAPEUTIC AREA
Not Available
USE
Patulin, a mycotoxin, has been reported to contain antibiotic characteristics. This compound displays the ability to specifically inhibit Na+-K+ ATPase. In murine studies, Patulin was found to inhibit protein prenylation in cells. Mechanistic studies suggest that Patulin reduces incorporation of mevalonate into proteins and prevents protein transferase action, which is required for protein prenylation. Additional experiments show that this mycotoxin also inhibits cell-free microtubule polymerization by covalently reacting with thiol groups of microtubule proteins.
Merck Index
13.7125.2001
RTECS
LV2625000
Handling
Do not breathe dust. Do not get in eyes, on skin, or on clothing. Do not ingest. Use only in area provided with appropriate exhaust ventilation. Wear personal protective equipment.
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
GHS PICTOGRAMS
Handling Do not breathe dust. Do not get in eyes, on skin, or on clothing. Do not ingest. Use only in area provided with appropriate exhaust ventilation. Wear personal protective equipment.
We found other products you might like!
To Top