Paxilline is a tremorogenic indole diterpene and a potent, selective, and reversible inhibitor of high-conductance Ca2+-activated potassium (BKCa) channels in murine smooth muscle cells by stimulating binding of charybdotoxin (ChTX) to maxi-K channels and blocking the channels.
It is reported that a gain-of-function in BK-channel is related to spontaneous seizures in both animal models and humans. For example: epilepsy and paroxysmal movement disorder. Paxilline can cross the blood-brain barrier and downregulate the abnormal activity of gain-of-function in BK-channel.
• BK-channel antagonist
• Anticonvulsant reagent
• Neuronal diseases study
Not for human therapeutic use or for medicinal purposes. For research applications only.
|Handling||Warning.Potent Neurotoxin. Wear gloves/mask when handling product. Avoid contact by all means of exposure. Protect from Light. This product should be handled only by qualified experienced professionals. Wash thoroughly after handling this.|
|UN #'S||UN 3462|