Paxilline, Penicillium paxilli

SKU
P-1029
  • CAS:57186-25-1
  • Formula:C27H33O4
  • MW:435.6
  • Appearance:White crystalline powder
  • Purity:≥97%

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Product Name Qty
Paxilline, Penicillium paxilli
50 mg
$654.97
Paxilline, Penicillium paxilli
5 mg
$148.07
Paxilline, Penicillium paxilli
10 mg
$281.36

Description

Paxilline is a tremorogenic indole diterpene and a potent, selective, and reversible inhibitor of high-conductance Ca2+-activated potassium (BKCa) channels in murine smooth muscle cells by stimulating binding of charybdotoxin (ChTX) to maxi-K channels and blocking the channels.

It is reported that a gain-of-function in BK-channel is related to spontaneous seizures in both animal models and humans. For example: epilepsy and paroxysmal movement disorder. Paxilline can cross the blood-brain barrier and downregulate the abnormal activity of gain-of-function in BK-channel.

 

Applications

• BK-channel antagonist

• Anticonvulsant reagent

• Neuronal diseases study

 

References

“Paxilline Inhibition of the Alpha-subunit of the High-conductance Calcium-activated Potassium Channel”

“Anticonvulsant effects of the BK‐channel antagonist paxilline”

“Paxilline inhibits BK channels by an almost exclusively closed-channel block mechanism”

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
2H-1-Benzopyrano(5',6':6,7)indeno(1,2-b)indol-3(4bh)-one, 5,6,6a,7,12,12b,12c,13,14,14a-decahydro-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-, (2-alpha,4b-beta,6a-alpha,12b-beta,12c-alpha,14a-beta)-; 2H-Pyrano(2'',3'':5',6')benz(1',2':6,7)indeno(1,2-b)indol-3(4bH)-one, 5,6,6a,7,12,12b,12c,13,14,14a-decahydro-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-, (2R,4bS,6aS,12bS,12cR,14aS)-; NSC 658707; UNII-3T9U9Z96L7
SKU
P-1029
CAS #
57186-25-1
Chemical Name
(1S,2R,5S,7R,11S,14S)-11-hydroxy-7-(2-hydroxypropan-2-yl)-1,2-dimethyl-6-oxa-23-azahexacyclo[12.10.0.02,11.05,10.016,24.017,22]tetracosa-9,16(24),17,19,21-pentaen-8-one
Chemical Formula
C27H33O4
Molecular Weight
435.6
Appearance
White crystalline powder
Purity
≥97%
Solubility
Soluble in DMSO, ethanol, petrol ether
Melting Point
283-285ºC
Storage Temp
-10°C ~-25°C
USE
A tremogenic indole alkaloid and potassium channel blocker.
MDL NUMBER
MFCD00083464
CHEMACX
X3470122-3
INCHI
InChI=1S/C27H33NO4/c1-24(2,30)23-20(29)14-18-21(32-23)10-11-25(3)26(4)15(9-12-27(18,25)31)13-17-16-7-5-6-8-19(16)28-22(17)26/h5-8,14-15,21,23,28,30-31H,9-13H2,1-4H3/t15-,21-,23-,25+,26+,27+/m0/s1
SMILES
C[C@]12CC[C@H]3C(=CC(=O)[C@H](O3)C(C)(C)O)[C@@]1(CC[C@@H]4[C@@]2(c5c(c6ccccc6[nH]5)C4)C)O
Peptide sequence
Not Applicable
RTECS
DJ2830000
UN #'S
UN 3462
PACKING GROUP
II
HAZARD CLASS
Not Applicable
Handling
Warning.Potent Neurotoxin. Wear gloves/mask when handling product. Avoid contact by all means of exposure. Protect from Light. This product should be handled only by qualified experienced professionals. Wash thoroughly after handling this.
Certificate of Analysis 1
GHS PICTOGRAMS
Handling Warning.Potent Neurotoxin. Wear gloves/mask when handling product. Avoid contact by all means of exposure. Protect from Light. This product should be handled only by qualified experienced professionals. Wash thoroughly after handling this.
UN #'S UN 3462
Packing Group II
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