SDS
CofA
Cell-permeable. A potent and selective multi-targeted tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor and c-kit, key proteins responsible for tumor growth and angiogenesis.
More Information
Alternate Name/Synonyms
GW-786034
SKU
P-2385
CAS #
444731-52-6
Chemical Name
5-[4-[(2,3-DIMETHYL-2H-INDAZOL-6-YL)-METHYL-AMINO]-PYRIMIDIN-2-YLAMINO]-2-METHYL-BENZENESULFONAMIDE
Chemical Formula
C21H23N7O2S
Molecular Weight
437.52
Appearance
White to off-white Solid
Purity
98% by HPLC
Solubility
DMSO (~ 8 mg/ml)
Melting Point
301-313 °C
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
Pazopanib is a potent and selective multi-targeted tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor (Flk-1), platelet-derived growth factor receptor (PDGFR) and c-kit
MDL NUMBER
MFCD11616589
CHEMACX
X1722103-5
INCHI
InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25)
SMILES
CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Protect from light and air
| Handling | Protect from light and air |
|---|---|
| UN #'S | Not Applicable |
| Packing Group | Not Applicable |
