PBIT, JARID1 lysine demethylase inhibitor

SKU
P-3329
  • CAS:2514-30-9
  • Formula:C14H11NOS
  • MW:241.31
  • Appearance:Off-white solid
  • Purity:98% by TLC NMR (Conforms)
Product Name Qty
PBIT, JARID1 lysine demethylase inhibitor
25 mg
$235.88

PBIT (2514-30-9) is a potent and selective inhibitor of JARID1 (IC50 = 3, 4.9 and 6 μM for JARID1B, 1A and 1C, respectively). The JARID1 (Jumonji AT-Rich Interactive Domain 1) family of lysine demethylases demethylates the trimethylated lysine 27 in histone H3 (H3K4me3). PBIT is selective for JARID1 over UTX and JMJD3. Treatment of cells with PBIT inhibits the demethylation of H3K4me3. It inhibits proliferation of breast cancer cell lines expressing high levels of JARID1B1.

 

More Information
SKU
P-3329
CAS #
2514-30-9
Chemical Name
2-(4-Methylphenyl)-1,2-benzisothiazol-3(2H)-one
Chemical Formula
C14H11NOS
Molecular Weight
241.31
Appearance
Off-white solid
Purity
98% by TLC NMR (Conforms)
Solubility
Soluble in DMSO (up to 24 mg/ml) or in Ethanol (up to 5 mg/ml)
Stability
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Storage Temp
-20°C (des.)
Hazard Image
Yes
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