PD-0325901

SKU
P-1703
  • CAS:391210-10-9
  • Formula:C16H14F3IN2O4
  • MW:482.2
  • Appearance:Off-White Solid
  • Purity:98% by HPLC

2

0

0

0

Product Name Qty
PD-0325901
5 mg
$313.24
PD-0325901
25 mg
$1,099.19
PD-0325901
2 mg
$176.55

A selective and ATP non-competitive MEK inhibitor that suppresses the phosphorylation of ERK in murine colon 26 tumors (IC=0.33 nM). In combination with the GSK-3 inhibitor CHIR99021, prevents cell differentiation and sustains self-renewal ofembryonic stem (ES) cells.

More Information
SKU
P-1703
CAS #
391210-10-9
Chemical Name
N-[(2R)-2,3-DIHYDROXYPROPOXY]-3,4-DIFLUORO-2-(2-FLUORO-4-IODO-ANILINO)BENZAMIDE
Chemical Formula
C16H14F3IN2O4
Molecular Weight
482.2
Appearance
Off-White Solid
Purity
98% by HPLC
Solubility
DMSO or Ethanol (~20 mg/ml)
Melting Point
117-119 °C
Storage Temp
Keep cool and dry. Store at -20°C
THERAPEUTIC AREA
Oncological Disorders
USE
An inhibitor of MEK and suppressor of ERK phosphorylation use in cancer
MDL NUMBER
MFCD08435926
CHEMACX
X1755696-6
INCHI
InChI=1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1
SMILES
C1=CC(=C(C=C1I)F)NC2=C(C=CC(=C2F)F)C(=O)NOC[C@@H](CO)O
UN #'S
UN 2811
PACKING GROUP
III
Handling
Do not take internally. Wear gloves and mask when handling the product.Avoid contact by all modes of exposure.
GHS PICTOGRAMS
Handling Do not take internally. Wear gloves and mask when handling the product.Avoid contact by all modes of exposure.
UN #'S UN 2811
Packing Group III
To Top