PD-0325901
SKU
P-1703
- CAS:391210-10-9
- Formula:C16H14F3IN2O4
- MW:482.2
- Appearance:Off-White Solid
- Purity:98% by HPLC
SDS
CofA
A selective and ATP non-competitive MEK inhibitor that suppresses the phosphorylation of ERK in murine colon 26 tumors (IC=0.33 nM). In combination with the GSK-3 inhibitor CHIR99021, prevents cell differentiation and sustains self-renewal ofembryonic stem (ES) cells.
More Information
SKU
P-1703
CAS #
391210-10-9
Chemical Name
N-[(2R)-2,3-DIHYDROXYPROPOXY]-3,4-DIFLUORO-2-(2-FLUORO-4-IODO-ANILINO)BENZAMIDE
Chemical Formula
C16H14F3IN2O4
Molecular Weight
482.2
Appearance
Off-White Solid
Purity
98% by HPLC
Solubility
DMSO or Ethanol (~20 mg/ml)
Melting Point
117-119 °C
Storage Temp
Keep cool and dry. Store at -20°C
THERAPEUTIC AREA
Oncological Disorders
USE
An inhibitor of MEK and suppressor of ERK phosphorylation use in cancer
MDL NUMBER
MFCD08435926
CHEMACX
X1755696-6
INCHI
InChI=1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1
SMILES
C1=CC(=C(C=C1I)F)NC2=C(C=CC(=C2F)F)C(=O)NOC[C@@H](CO)O
UN #'S
UN 2811
PACKING GROUP
III
Handling
Do not take internally. Wear gloves and mask when handling the product.Avoid contact by all modes of exposure.
| GHS PICTOGRAMS |
|
|---|---|
| Handling | Do not take internally. Wear gloves and mask when handling the product.Avoid contact by all modes of exposure. |
| UN #'S | UN 2811 |
| Packing Group | III |