PD 153035 Hydrochloride

SKU

P-2389

CAS:153436-54-5
Formula:C₁₆H₁₄BrN₃O₂.HCl
MW:396.67
Appearance:White to off-white solid
Purity:≥95% by HPLC

SDS

CofA

Product Name	Qty
PD 153035 Hydrochloride 2 mg $108.21

Details

An extremely potent and specific inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC₅₀ = 25 pM). Inhibits other purified kinases only at micromolar or higher concentrations.

Specifications

More Information

SKU

P-2389

CAS #

153436-54-5

Chemical Name

N-(3-Bromophenyl)-6,7-dimethoxy-4-quinazolinamine hydrochloride: AG 1517; NSC-669364; SU 5271

Chemical Formula

C₁₆H₁₄BrN₃O₂.HCl

Molecular Weight

396.67

Appearance

White to off-white solid

Purity

≥95% by HPLC

Solubility

DMSO (5 mg/ml)

Storage Temp

-20°C

Reviews

Safety

Citations

Citations	Studies of cell signaling in a reconstructed human epidermis exposed to sensitizers: IL-8 synthesis and release depend on EGFR activation
	Cholesterol depletion upregulates involucrin expression in epidermal keratinocytes through activation of p38
	Internalization of EGF receptor following lipid rafts disruption in keratinocytes is delayed and dependent on p38 MAPK activation
	SnoN/SkiL expression is modulated via arsenic trioxide-induced activation of the PI3K/AKT pathway in ovarian cancer cells
	Phenotypic modulation of human cardiospheres between stemness and paracrine activity, and implications for combined transplantation in cardiovascular regeneration