PD-173074

SKU
P-2390
  • CAS:219580-11-7
  • Formula:C28H41N7O3
  • MW:523.67
  • Appearance:Crystalline Solid
  • Purity:98% by TLC

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Product Name Qty
PD-173074
1 mg
$83.75

A potent and selective FGFR1 tyrosine kinase inhibitor (IC= 21.5 nM). Blocking of the FGFR signaling pathway by PD 173074 leads to self-renewal of stem cells via ERK1/2 activation. Treatment of FGF2-expressing human multipotent adipose-derived stem cells with PD173074 decreases dramatically their clonogenicity and differentiation potential.

More Information
Alternate Name/Synonyms
N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N-(1,1-dimethylethyl)urea
SKU
P-2390
CAS #
219580-11-7
Chemical Name
N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N’-(1,1-dimethylethyl)urea
Chemical Formula
C28H41N7O3
Molecular Weight
523.67
Appearance
Crystalline Solid
Purity
98% by TLC
Solubility
Soluble in DMSO (10 mg/ml)
Stability
N/A
Melting Point
82-85 °C
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
The Fibroblast Growth Factor Receptor Inhibitor PD173074 Blocks Small Cell Lung Cancer
MDL NUMBER
MFCD08705327
CHEMACX
X1544144-6
PubChecm ID
N/A
INCHI
InChI=1S/C28H41N7O3/c1-8-35(9-2)13-11-10-12-29-26-30-18-20-16-23(19-14-21(37-6)17-22(15-19)38-7)25(31-24(20)32-26)33-27(36)34-28(3,4)5/h14-18H,8-13H2,1-7H3,(H3,29,30,31,32,33,34,36)
SMILES
CCN(CC)CCCCNc1ncc2cc(c(nc2n1)NC(=O)NC(C)(C)C)c3cc(cc(c3)OC)OC
Handling
Protect from air and light
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GHS PICTOGRAMS
Handling Protect from air and light
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