- Appearance:A crystalline Solid
The mitogen-activated protein (MAP) kinase intracellular signaling pathways are involved in the regulation of various cellular functions.One of these pathways, the Raf/MEK/ERK pathway, plays a major role in the regulation of cellular growth, differentiation, and proliferation. The modulation of this cascade has been studied as a useful approach to treating proliferative disorders such as cancer.PD 184161 is a potent and selective inhibitor of MEK1/2 with an ICvalue that ranges from 10-100 nM. More effective at inhibiting phosphorylation of ERK1/2 than the selective MEK inhibitors, PD098059 and U0126, PD 184161 is useful both .in vitro and .in vivo for studying the pharmacological role of the Raf/MEK/ERK pathway.PD 184161 is structurally related to clinically-studied MEK inhibitors PD184352 (CI-1040) and PD 325901 and has been shown to inhibit cell proliferation, induce apoptosis, and possess anti-tumor activity in MEK-dependent cancers.
A crystalline Solid
Soluble in 10 mg/mL 100% ethanol, 30 mg/mL of DMSO or DMF; very sparnigly in aqueous buffers
The effects of a novel MEK inhibitor PD184161 on MEK-ERK signaling and growth in human liver cancer
Certificate of Analysis 1
|UN #'S||UN 3077|