PD-98059

SKU
P-1019
  • CAS:167869-21-8
  • Formula:C16H13NO3
  • MW:267.3
  • Appearance:Pale to Yellow Solid
  • Purity:95%
Product Name Qty
PD-98059
5 mg
$79.74
PD-98059
10 mg
$119.60
Cell-permeable, potent and specific inhibitor of MAP Kinase (MEK or MAPK/ERK). By selectively blocking the activity of MEK, it also inhibits the phosphorylation and activation of MAP kinase.Transcriptional activation of the IL31 gene by NFAT and STAT6.Differential Role of PKC Isoforms in GnRH and Phorbol 12-Myristate 13-Acetate Activation of Extracellular Signal-Regulated Kinase and Jun N-Terminal Kinase.Glycogen Synthase Kinase-3 Plays a Central Role in Mediating Glucocorticoid-Induced Apoptosis.Effect of Oncostatin M on Uridine Diphosphate-5'-Glucuronosyltransferase 1A1 through Cross Talk with Constitutive Androstane Receptor.Loss of E-Cadherinmediated CellCell Contacts Activates a Novel Mechanism for Up-Regulation of the Proto-Oncogene.
More Information
Alternate Name/Synonyms
2'-Amino-3'methoxyflavone
SKU
P-1019
CAS #
167869-21-8
Chemical Name
2'-Amino-3'methoxyflavone
Chemical Formula
C16H13NO3
Molecular Weight
267.3
Appearance
Pale to Yellow Solid
Purity
95%
Solubility
DMSO
Melting Point
164-165 °C
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
Potent and specific inhibitor of MAP Kinase (MEK or MAPK/ERK) use in cancer
MDL NUMBER
MFCD00671789
CHEMACX
X1038243-7
INCHI
InChI=1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3
SMILES
COc1cccc(c1N)c2cc(=O)c3ccccc3o2
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Store in Tightly Sealed Vial Protect from Light
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
Handling Store in Tightly Sealed Vial Protect from Light
UN #'S Not Applicable
Packing Group Not Applicable
Citations Pyrrolidine dithiocarbamate-induced macrophage inflammatory protein-2 gene expression is NF-kappaB-independent but c-Jun-dependent in macrophage cell line RAW 264.7
Circadian profiles in the embryonic chick heart: L-type voltage-gated calcium channels and signaling pathways
Circadian regulation of retinoschisin in the chick retina
Modulation of coxsackie-adenovirus receptor expression for increased adenoviral transgene expression
MicroRNA 10b promotes abnormal expression of the proto-oncogene c-Jun in metastatic breast cancer cells
Cathepsin L derived from skeletal muscle cells transfected with bFGF promotes endothelial cell migration
Molecular mechanism of cofilin dephosphorylation by ouabain
Loss of E-cadherin-mediated cell-cell contacts activates a novel mechanism for up-regulation of the proto-oncogene c-Jun
The poly-γ-d-glutamic acid capsule surrogate of the Bacillus anthracis capsule induces nitric oxide production via the platelet activating factor receptor signaling pathway
Pituitary Adenylate Cyclase Activating Polypeptide- Mediated Intracrine Signaling in the Testicular Germ Cells
Oscillating pressure treatment upregulates connexin43 expression in skeletal myoblasts and enhances therapeutic efficacy for myocardial infarction
Exogenous ceramide-1-phosphate (C1P) and phospho-ceramide analogue-1 (PCERA-1) regulate key macrophage activities via distinct receptors
Gastrin-releasing peptide induces monocyte adhesion to vascular endothelium by upregulating endothelial adhesion molecules
Leptin induces hypertrophy via p38 mitogen-activated protein kinase in rat vascular smooth muscle cells
Nuclear Factor E2–Related Factor 2–Mediated Induction of NAD(P)H:Quinone Oxidoreductase 1 by 3,5-Dimethoxy-trans-stilbene
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