PD184352

SKU
P-1705
  • CAS:212631-79-3
  • Formula:C17H14CIF2IN2O2
  • MW:478.67
  • Appearance:White to off-white Solid
  • Purity:99% by HPLC

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Product Name Qty
PD184352
5 mg
$301.86
PD184352
25 mg
$871.39
PD184352
1 mg
$100.25
A highly potent ATP-noncompetitive MEK inhibitor. It inhibits MEK with anin vitro IC of 1-1.3 nM. It does not inhibit other kinases. Highly recommended tool to inhibit MKK1 or MKK1 plus MKK5.
More Information
Alternate Name/Synonyms
CI-1040
SKU
P-1705
CAS #
212631-79-3
Chemical Name
2-(2-CHLORO-4-IODOANILINO)-N-(CYCLOPROPYLMETHOXY)-3,4-DIFLUOROBENZAMIDE
Chemical Formula
C17H14CIF2IN2O2
Molecular Weight
478.67
Appearance
White to off-white Solid
Purity
99% by HPLC
Solubility
DMSO (600 mg/ml)
Melting Point
166-169 °C
Storage Temp
Keep cool and dry, Store at - 20°C
THERAPEUTIC AREA
Oncological Disorders
USE
PD184352 a targeted signal transduction inhibitor of MEK use in the treatment of breast and other cancers.
MDL NUMBER
MFCD02683961
CHEMACX
X1608406-7
INCHI
InChI=1S/C17H14ClF2IN2O2/c18-12-7-10(21)3-6-14(12)22-16-11(4-5-13(19)15(16)20)17(24)23-25-8-9-1-2-9/h3-7,9,22H,1-2,8H2,(H,23,24)
SMILES
C1CC1CONC(=O)C2=C(C(=C(C=C2)F)F)NC3=C(C=C(C=C3)I)Cl
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
UN 3077
PACKING GROUP
III
HAZARD CLASS
Not Applicable
Handling
Do not take internally. Wear gloves and a mask when handling the product.Avoid contact by all modes of exposure.
GHS PICTOGRAMS
Handling Do not take internally. Wear gloves and a mask when handling the product.Avoid contact by all modes of exposure.
UN #'S UN 3077
Packing Group III
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