PDGFRTyrosine Kinase Inhibitor II

SKU
P-1687
  • CAS:249762-74-1
  • Formula:C21H18N2O3
  • MW:346.4
  • Appearance:Solid
  • Purity:97%
Product Name Qty
PDGFRTyrosine Kinase Inhibitor II
1 mg
$203.90
A cell permeable bis(1H-2-indolyl)-1-methanone compound that acts as a highly selective, ATP-competitive and reversible inhibitor of platelet-derived growth factor receptor tyrosine kinase. Also potently inhibits Flt3 activity. Sensitzes 32D cells to radiation-induced apoptosis and inhibits prliferation of TEL-Flt3-transfected BA-F3 cells. May also serce as a prodrug for of the PDGF Receptor Tyrosine Kinase Inhibitor I in cells.
More Information
SKU
P-1687
CAS #
249762-74-1
Chemical Name
(5-BUTANOATE-1H-2-INDOLYL)(1H-2-INDOLYL)-METHANONE
Chemical Formula
C21H18N2O3
Molecular Weight
346.4
Appearance
Solid
Purity
97%
Solubility
DMSO
Storage Temp
+2°C to +8°C
THERAPEUTIC AREA
Not Available
USE
A cell-permeable isothiourea compound that perturbs MreB function
MDL NUMBER
MFCD06411445
CHEMACX
Not Applicable
INCHI
InChI=1S/C21H18N2O3/c1-2-5-20(24)26-15-8-9-17-14(10-15)12-19(23-17)21(25)18-11-13-6-3-4-7-16(13)22-18/h3-4,6-12,22-23H,2,5H2,1H3
SMILES
CCCC(=O)Oc1ccc2c(c1)cc([nH]2)C(=O)c3cc4ccccc4[nH]3
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Standard handling
HandlingStandard handling
UN #'SNot Applicable
Packing GroupNot Applicable
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