Pemetrexed Disodium

SKU
P-7900
  • CAS:357166-29-1
  • Formula:C20H19N5Na2O6 [7H2O]
  • MW:597.5 Da
  • Appearance:White powder
  • Purity:>98% (TLC, HPLC)

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Product Name Qty
Pemetrexed Disodium
50 mg
$255.00
Pemetrexed Disodium
10 mg
$76.50

Description

Pemetrexed is a multi-targeted antifolate with antitumor activity. It potently inhibits folate-dependent enzymes involved in both purine and pyrimidine synthesis including thymidylate synthase (Ki = 109 nM), dihydrofolate reductase (Ki = 7 nM), glycinamide ribonucleotide formyltransferase (Ki = 9.3 μM), and aminoimidazole carboxamide ribonucleotide formyltransferase (Ki = 3.6 μM)1. A clinically useful anticancer agent2. Indirectly activates the metabolic kinase AMPK and consequently influences the mTORC1 pathway in human carcinomas3. Activation of AMPK is associated with pemetrexed resistance4. Induces G0/G1-phase cell cycle arrest in esophageal squamous cell carcinoma cells5.

References:

1. Shih, Chuan, et al. "LY231514, a pyrrolo [2, 3-d] pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes." Cancer research 57.6 (1997): 1116-1123.

2. Hanauske, Axel-R., et al. "Pemetrexed disodium: a novel antifolate clinically active against multiple solid tumors." The Oncologist 6.4 (2001): 363-373.

3. Rothbart, Scott B., Alexandra C. Racanelli, and Richard G. Moran. "Pemetrexed indirectly activates the metabolic kinase AMPK in human carcinomas." Cancer research 70.24 (2010): 10299-10309.

4. Qin, Yiyang, et al. "AMPK activation induced in pemetrexed‐treated cells is associated with development of drug resistance independently of target enzyme expression." Molecular oncology 13.6 (2019): 1419-1432.

5. Li, Xinying, et al. "Pemetrexed exerts anticancer effects by inducing G0/G1‑phase cell cycle arrest and activating the NOXA/Mcl‑1 axis in human esophageal squamous cell carcinoma cells." Oncology letters 17.2 (2019): 1851-1858.

 

More Information
Alternate Name/Synonyms
Pemetrexed 2Na; Pemetrexed sodium hydrate; Pemetrexed disodium heptahydrate; Alimta; N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt; LY231514
SKU
P-7900
CAS #
357166-29-1
Chemical Name
disodium;(2S)-2-[[4-[2-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioate;heptahydrate
Chemical Formula
C20H19N5Na2O6 [7H2O]
Molecular Weight
597.5 Da
Appearance
White powder
Purity
>98% (TLC, HPLC)
Solubility
May be dissolved in Water (100 mg/mL)
Storage Temp
Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month.
THERAPEUTIC AREA
Oncological Disorders
USE
A multi-enzyme and tumor cell proliferation inhibitor.
Handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.Further processing of solid materials may result in the formation of combustible dusts. The potential for combustible dust formation should be taken into consideration before additional processing occurs. Provide appropriate exhaust ventilation at places where dust is formed.
GHS PICTOGRAMS
Handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols.Further processing of solid materials may result in the formation of combustible dusts. The potential for combustible dust formation should be taken into consideration before additional processing occurs. Provide appropriate exhaust ventilation at places where dust is formed.
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