Phenylhexyl Isothiocyanate

SKU
P-2951
  • CAS:133920-06-6
  • Formula:C13H17NS
  • MW:219.35
  • Appearance:Clear colorless liquid
  • Purity:≥98%
Product Name Qty
Phenylhexyl Isothiocyanate
500 mg
$462.26
Phenylhexyl isothiocyanate
25 mg
$84.15
Phenylhexyl Isothiocyanate
100 mg
$153.83
Phenylhexyl Isothiocyanate
250 mg
$308.21

Isothiocyanates are compounds typically found in plants of the Brassicaceae family, including broccoli, cabbage, and radish. Isothiocyanates are best known for their antioxidative, anticancer chemotherapeutic, chemopreventive, anti-angiogenic, and antibiotic properties. In vitro, phenhexyl isothiocyanate (PHITC) increases caspase 3 activity and cleavage of poly(ADP)-ribose polymerase (PARP), inducing caspase-mediated apoptosis in cellular models. This compound decreases oxidation of carcinogen NNK and increases activity of NADPH:quinone oxidoreductase and glutathione S-transferase in vitro and in vivo. PHITC inhibits histone deacetylase (HDAC) activity, IL-6 receptor production, and VEGF expression; it also induces mitochondrial membrane depolarization and apoptosis in myeloma cells. In leukemia cells, PHITC inhibits expression of cyclin and increases expression of cyclin dependent kinase (CDK) inhibitors, inducing apoptosis and inhibiting growth of xenografts of these cells in animals.

More Information
Alternate Name/Synonyms
6-Phenylhexyl isothiocyanate; PHITC
SKU
P-2951
CAS #
133920-06-6
Chemical Name
6-isothiocyanatohexylbenzene
Chemical Formula
C13H17NS
Molecular Weight
219.35
Appearance
Clear colorless liquid
Purity
≥98%
Solubility
Soluble in oraganic solvents.
Storage Temp
-20°C
Hazard Image
Yes
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