Phorbol-12-myristate-13-acetate

SKU
P-1039
  • CAS:16561-29-8
  • Formula:C36H56O8
  • MW:616.8
  • Appearance:White to off-white solid.
  • Purity:≥99%

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Product Name Qty
Phorbol-12-myristate-13-acetate
1 mg
$39.08
Phorbol-12-myristate-13-acetate
5 mg
$155.97

Potent mouse skin tumor promoter. Also activates Protein Kinase C. Frequent and Strong Antibody-Mediated Natural Killer Cell Activation in Response to HIV-1 Env in Individuals with Chronic HIV-1 Infection. HIV-1-Specific Interleukin-21+ CD4+ T Cell Responses Contribute to Durable Viral Control through the Modulation of HIV-Specific CD8+ T Cell Function. Upregulation of voltage-gated Na+ channels by long-term activation of the ghrelin-growth hormone secretagogue receptor in clonal GC somatotropes. A T-bet-Independent Role for IFN-/ in Regulating IL-2 Secretion in Human CD4+ Central Memory T Cells. Blockade of Virus Infection by Human CD4+ T Cells via a Cytokine Relay Network.

More Information
Alternate Name/Synonyms
PMA; PKC activator;TPA; 12-O-Tetradecanoyl-phorbol13-acetate; Phorbol myristate acetate
SKU
P-1039
CAS #
16561-29-8
Chemical Name
(1AR,1BS,4AR,7AS,7BS,8R,9R,9AS)-9A-(ACETYLOXY)-1A,1B,4,4A,5,7A,7B,8,9,9A-DECAHYDRO-4A,7B-DIHYDROXY-3-(HYDROXYMETHYL)-1,1,6,8-TETRAMETHYL-5-OXO-1H-CYCLOPROPA[3,4]BENZ[1,2-E]AZULEN-9-YL TETRADECANOATE
Chemical Formula
C36H56O8
Molecular Weight
616.8
Appearance
White to off-white solid.
Purity
≥99%
Solubility
Soluble in DMSO, methanol, 100% ethanol, acetone, ether or dimethylformamide; almost insoluble in aqueous buffers.
Melting Point
50-70 °C
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
It is used to stimulate division of B-cells during cytogenetic diagnosis of B-cell cancers such as chronic lymphocytic leukemia
Merck Index
Merck Index: 13.7417.2001
MDL NUMBER
MFCD00036736
CHEMACX
X1009782-4
INCHI
InChI=1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24?,27-,28?,30+,32+,34+,35+,36+/m0/s1
SMILES
CCCCCCCCCCCCCC(=O)O[C@@H]2C(C)[C@]1(O)C4/C=C(/C)C(=O)[C@@]4(O)CC(CO)=C/[C@H]1[C@H]3[C@]2(OC(C)=O)C3(C)C
RTECS
QH4377000
Handling
Warning.Toxic. Store in Tightly Sealed Vial
Citations_Hyperlink
http://ajpendo.physiology.org/cgi/reprint/296/5/E1148
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
GHS PICTOGRAMS
Handling Warning.Toxic. Store in Tightly Sealed Vial
Citations Upregulation of voltage-gated Na+ channels by long-term activation of the ghrelin-growth hormone secretagogue receptor in clonal GC somatotropes
The cytosolic domain of protein-tyrosine kinase 7 (PTK7), generated from sequential cleavage by a disintegrin and metalloprotease 17 (ADAM17) and γ-secretase, enhances cell proliferation and migration in colon cancer cells
The bioactive lipid 4-hydroxyphenyl retinamide inhibits flavivirus replication
Involvement of F-Actin Cytoskeleton for Microvilli Formation of Jurkat T Lymphocyte
DIDOX MODULATES REACTIVE OXYGEN SPECIES PRODUCTION AND INFLAMMATORY EVENTS INDUCED BY LIPOPOLYSACCHARIDE (LPS) AND ARYL HYDROCARBON RECEPTOR (AHR) LIGANDS IN RAW 264.7 MURINE MACROPHAGES.
Type I Interferon Signaling Pathway May Be Involved in Optimal Interleukin-2 Production in CD4+ T Cells
Reciprocal Regulation of CD4+ and CD8+ T Lymphocyte Effector and Memory Fates by Interleukin 12 and Type 1 Interferon
Tumor necrosis factor alpha and endothelin-1 increase P-glycoprotein expression and transport activity at the blood-brain barrier
CD4(+) T cells specific to a glomerular basement membrane antigen mediate glomerulonephritis
Upregulation of osteopontin by osteocytes deprived of mechanical loading or oxygen
Blockade of virus infection by human CD4+ T cells via a cytokine relay network
Cutting Edge: A T-bet-Independent Role for IFN- /  in Regulating IL-2 Secretion in Human CD4+ Central Memory T Cells
IFN-  Is Not Sufficient to Drive Th1 Development Due to Lack of Stable T-bet Expression
Galangin and kaempferol suppress phorbol-12-myristate-13-acetate-induced matrix metalloproteinase-9 expression in human fibrosarcoma HT-1080 cells
Polyenoic Fatty Acid Ratios Alter Fibroblast Collagen Production Via PGE2 and PGE Receptor Subtype Response
Regulation of Effector and Memory Development of Human CD4+ T Cells by Interleukin 12 and Type I Interferon
Investigating the Anti-viral Property of Verotoxin and its Receptor Gb3 in Preventing Primary HIV-1 Infection
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