Phosphoramidon

SKU
P-1101
  • CAS:119942-99-3
  • Formula:C23H32N3O10P • 2Na
  • MW:587.5 Da
  • Appearance:White powder
  • Purity:≥97%

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Product Name Qty
Phosphoramidon
25 mg
$803.55
Phosphoramidon
1 mg
$61.81
Phosphoramidon
5 mg
$191.28

Inhibits neutral endopeptidase 24.11 (NEP, neprilysin; EC 3.4.24.11)  (Ki=2nM), a cell surface zinc metalloprotease which cleaves bioactive peptides such as bradykinin, neurotensin, and enkephalin. Also inhibits neprilysin 2 (Ki~2nM). Potent inhibitor of endothelin-converting enzyme (ECE) (IC50=0.68 μM).

 

 

More Information
Alternate Name/Synonyms
N-(α-Rhamno­pyranosyl­oxy­hydroxy­phosphinyl)-Leu-Trp disodium salt; N-(α-Rhamno­pyranosyl­phos­phono)-L-leucyl-L-tryptophan disodium salt
SKU
P-1101
CAS #
119942-99-3
Chemical Name
disodium;(2S)-3-(1H-indol-3-yl)-2-[[(2S)-4-methyl-2-[[oxido-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyphosphoryl]amino]pentanoyl]amino]propanoate
Chemical Formula
C23H32N3O10P • 2Na
Molecular Weight
587.5 Da
Appearance
White powder
Purity
≥97%
Solubility
Soluble in water, DMSO or methanol.
Melting Point
N/A
Preparation
N/A
Storage Temp
-20°C, desiccated
THERAPEUTIC AREA
Neurodegenrative Diseases
USE
Phosphoramidon is an inhibitor of CD10 (neutral endopeptidase 24.11, NEP), metalloproteases (MMPs), and Neprilysin-2 (NEP2), which belong to a group of type II integral membrane glycoproteins. In addtion, the NEP enzyme has been shown to play a role in the regulation of neuropeptide signaling and in the metabolism of bioactive peptides via plasma membranes. NEP2 is a homologue of NEP with a high degree of sequence identity, however, research shows that they have different physiological actions. Studies show that phosphoramidon and thiorphan (sc-201287), another NEP inhibitor, can increase nitrile production. Additionally, LNCaP cell studies show that phosphoramidon can inhibit the metabolism of neurotensin (NT). Phosphoramidon is an inhibitor of endothelial converting enzyme (ECE). It increases the production of β-amyloid protein, but not amyloid precursor protein, indicating that abnormal amyloid processing in Alzheimer′s disease may be carried out by a metallo-endopeptidase.
Merck Index
N/A
RTECS
N/A
Handling
Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire protection.
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
GHS PICTOGRAMS
Handling Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire protection.
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