PI-103

SKU
P-2394
  • CAS:371935-74-9
  • Formula:C19H16N4O3
  • MW:348.36
  • Appearance:Off-White Solid
  • Purity:98% by HPLC
Product Name Qty
PI-103
5 mg
$370.19
PI-103
1 mg
$102.52
A cell-permeable, ATP-competitive inhibitor of phosphatidylinositol 3-kinase (PI3K) family members with selectivity toward DNA-PK, PI3K (p110), and mTOR. The ICvalues are 2, 8, 20, 26, 48, 83, 88, 150 nM for DNA-PK, p110, mTORC1, PI3-KC2, p110, mTORC2, p110, and p110, respectively. Inhibits growth of human tumor xenografts in mice in vivo.
More Information
Alternate Name/Synonyms
3-(4-(4-Morpholinyl)pyrido[3,2:4,5]furo[3,2-d]pyrimidin-2-yl)phenol
SKU
P-2394
CAS #
371935-74-9
Chemical Name
3-(4-(4-Morpholinyl)pyrido[3′,2′:4,5]furo[3,2-d]pyrimidin-2-yl)phenol
Chemical Formula
C19H16N4O3
Molecular Weight
348.36
Appearance
Off-White Solid
Purity
98% by HPLC
Solubility
DMSO (50 mM)
Melting Point
231.64 °C
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase and mTOR, has antileukemic activity in acute myelogenous leukemia (AML)
MDL NUMBER
MFCD11983145
CHEMACX
X1600468-5
INCHI
InChI=1S/C19H16N4O3/c24-13-4-1-3-12(11-13)17-21-15-14-5-2-6-20-19(14)26-16(15)18(22-17)23-7-9-25-10-8-23/h1-6,11,24H,7-10H2
SMILES
C1COCCN1C2=NC(=NC3=C2OC4=C3C=CC=N4)C5=CC(=CC=C5)O
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Protect from air and light
Handling Protect from air and light
UN #'S Not Applicable
Packing Group Not Applicable
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