Piceatannol

SKU
P-1015
  • CAS:10083-24-6
  • Formula:C14H12O4
  • MW:244.3
  • Appearance:Light pink powder
  • Purity:>98%
Product Name Qty
Piceatannol
50 mg
$444.23
Piceatannol
10 mg
$119.60

Selective protein tyrosine kinase Syk inhibitor (IC50~10 M). In RBL-2H3 cells the selective inhibition of Syk by piceatannol results in inhibition of Fc R1-mediated signaling. Besides that it works as activator of human deacetylase SIRT1.A natural stilbene and an analogue of Resveratrol (Prod.# R-1014). Besides antioxidative effects, piceatannol exhibits potential anticancer properties as shown by its ability to suppress proliferation of a wide variety of tumor cells, including leukemia, lymphoma; cancers of the breast, prostate, colon and melanoma. Also inhibits JAK-1 and Syk kinase; blocks adipogenesis of 3T3-L1 preadipocytes in a dose-dependent manner. Originally isolated from Euphorbia lagascae.

 

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More Information
SKU
P-1015
CAS #
10083-24-6
Chemical Name
3,4,3',5'-Tetrahydroxy-trans-stilbene
Chemical Formula
C14H12O4
Molecular Weight
244.3
Appearance
Light pink powder
Purity
>98%
Solubility
Soluble in DMSO (25 mg/ml), 100% ethanol (10 mg/ml), methanol, DMF, heptane (≥8 mg/ml), and xylene (≥8 mg/ml).
Storage Temp
+4ºC
Citations
ORIGINAL ARTICLES: Phosphoinositide 3-kinase is a novel target of piceatannol for inhibiting PDGF-BB-induced proliferation and migration in human aortic smooth muscle cells Keun Hwa Choi, Jong-Eun Kim, Nu Ry Song, Joe Eun Son, Mun Kyung Hwang, Sanguine Byun, Jong Hun Kim, Ki Won Lee, and Hyong Joo Lee Cardiovasc Res, Mar 2010; 85: 836 - 844.
Citations_Hyperlink
http://cardiovascres.oxfordjournals.org/cgi/reprint/85/4/836
Certificate of Analysis 1
Certificate of Analysis 2
Citations Rapid uptake of gold nanorods by primary human blood phagocytes and immunomodulatory effects of surface chemistry
Phosphoinositide 3-kinase is a novel target of piceatannol for inhibiting PDGF-BB-induced proliferation and migration in human aortic smooth muscle cells
Piceatannol attenuates 4-hydroxynonenal-induced apoptosis of PC12 cells by blocking activation of c-Jun N-terminal kinase
α-Glucosidase inhibitory effect of resveratrol and piceatannol
Metabolites of flavonoid compounds preserve indices of endothelial cell nitric oxide bioavailability under glucotoxic conditions
In silico and biochemical analyses identify quinone reductase 2 as a target of piceatannol
Inhibition of lipopolysaccharide-induced interferon regulatory factor 3 activation and protection from septic shock by hydroxystilbenes
A combination of isolated phytochemicals and botanical extracts lowers diastolic blood pressure in a randomized controlled trial of hypertensive subjects
Deletion of PI3K-p85alpha gene impairs lineage commitment, terminal maturation, cytokine generation and cytotoxicity of NK cells
Piceatannol suppresses the metastatic potential of MCF10A human breast epithelial cells harboring mutated H-ras by inhibiting MMP-2 expression
AKT/mTOR as Novel Targets of Polyphenol Piceatannol Possibly Contributing to Inhibition of Proliferation of Cultured Prostate Cancer Cells
The Effects of Metabolites of Polyphenols and Vitamin E on Modulating the High Glucose-induced Endothelial Dysfunction
Interactions of human primary immune cells with nanoparticles, two-dimensional micropatterns, hydrogels and three-dimensional nanofibres
Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1
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