Piericidin A, Streptomyces sp.

SKU
P-1474
  • CAS:2738-64-9
  • Formula:C25H37NO4
  • MW:415.6
  • Appearance:Pale yellow oil
  • Purity:95% by HPLC
Product Name Qty
Piericidin A, Streptomyces sp.
5 mg
$1,086.67
Piericidin A is the major analogue of a family of pyridyl antibiotics isolated from selected Streptomyces sp. It is a specific, potent inhibitor of NADH-ubiquinone oxidoreductase (Complex I) that binds to ubiquinone binding site(s). Piericidin A inhibits both mitochondrial and bacterial NADH-ubiquinone oxidoreductases, binding close to NUOD-NUOB interface.
More Information
Alternate Name/Synonyms
Shaoguanmycin B, Antibiotic MT 1882-I, Antibioic SN 198E, Antibiotic IT 143D, Piericidin A1
SKU
P-1474
CAS #
2738-64-9
Chemical Name
2-[(2E,4E,7E,9S,10S,11E)-10-HYDROXY-3,7,9,11-TETRAMETHYLTRIDECA-2,4,7,11-TETRAENYL]-5,6-DIMETHOXY-3-METHYLPYRIDIN-4-OL
Chemical Formula
C25H37NO4
Molecular Weight
415.6
Appearance
Pale yellow oil
Purity
95% by HPLC
Solubility
Soluble in water (>1 mg/ml) at 25 °C, ethanol, DMSO, DMF, and PBS pH 7.2.
Storage Temp
-20°C
THERAPEUTIC AREA
Not Available
USE
An antibiotic and a member of the Class I inhibitors that acts as an effective inhibitor of Complex I
MDL NUMBER
MFCD01677956
CHEMACX
X1378619-9
INCHI
InChI=1S/C25H37NO4/c1-9-18(4)22(27)19(5)15-17(3)12-10-11-16(2)13-14-21-20(6)23(28)24(29-7)25(26-21)30-8/h9-11,13,15,19,22,27H,12,14H2,1-8H3,(H,26,28)/b11-10+,16-13+,17-15+,18-9+/t19-,22+/m0/s1
SMILES
CC=C(C)C(C(C)C=C(C)CC=CC(=CCc1c(c(c(c(n1)OC)OC)O)C)C)O
Peptide sequence
Not Applicable
RTECS
YD4588000
UN #'S
UN 3172
PACKING GROUP
I
HAZARD CLASS
Not Applicable
Certificate of Analysis 1
Certificate of Analysis 2
UN #'SUN 3172
Packing GroupI
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